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Ludwig Maximilians Universität München

Adolf-Butenandt-Institut, Molekularbiologie

We are an independent junior research group embedded in the Department of Molecular Biology (chair Prof. Dr. Peter B. Becker) at the Adolf-Butenandt-Institut, LMU München.

Our group studies the mechanisms of nucleosome remodeling using biochemical, biophysical and structural methods.

The enormous size of eukaryotic genomic DNA necessitates elaborate mechanisms for its compaction to fit the confines of the nucleus. The primary compaction is achieved by wrapping DNA around histone proteins forming nucleosome particles. A static nucleosomal organization however would sterically obstruct fundamental cellular processes such as transcription and replication, which require naked DNA to work. The cell thus relies on processes that actively alter or ‘remodel’ the nucleosomal structure. These nucleosome remodeling enzymes use the energy of ATP hydrolysis and to move nucleosomes to neighboring stretches of DNA. The mechanism of nucleosome mobilization however is unknown.

Details


Adresse:
Ludwig Maximilians Universität München
Adolf-Butenandt-Institut, Molekularbiologie
Schillerstr. 44
80336 München
Deutschland
Arbeitsgebiet:
Forschung & Lehre
Expansion:
national
Mitarbeiteranzahl:
1-10
Gründungsjahr:
2012