Medizinische Hochschule Hannover
With the enthusiastic support of six important partner institutions, Hannover Medical School (MHH) has established a Cluster of Excellence in the area of Regenerative Biology and Reconstructive Therapies, acronym REBIRTH. Our programme integrates excellent training with innovative science and experimental as well as clinical medicine. Interactive basic research projects are designed to identify and evaluate cellular and molecular mediators that stimulate regeneration. We study both intrinsic pathways and milieu-dependent mechanisms which control epigenetic reprogramming, cell expansion, differentiation, migration, organogenesis and disease-specific regeneration. Driven by these insights, we test new approaches for regenerative therapies using novel (if possible somatic) cell sources which we engineer applying genetic, epigenetic, as well as scaffold-based principles. Expertise in various fields of engineering, chemistry, biophotonics and nanotechnology will support and supplement our research and development. Toward patient-focused, applied studies, the existing wide range of certified / accredited facilities for Good Practice (laboratory, manufacturing and clinical) and close industrial collaborations will be further expanded. Upscaling technologies and pro-active biosafety assessment complete our translational activities. Based upon MHH's recent key achievements and priorities we focus on disorders of blood (including immunity), heart, lung (respiratory tract) and liver. Our animal models span a wide range from rodents via domestic animals to non-human primates, including associated stem cell technologies. Carefully designed clinical trials are already being conducted and will be further expanded. Thereby, REBIRTH will represent an optimal partner for other domestic and international centres in regenerative medicine. Last but not least, sustainable training and diversity programmes represent major objectives of our concept.