Universität des Saarlandes
The research in our group focuses on DNA double-strand breaks (DSBs) which are probably the most severe threat to the maintenance of genomic integrity. They are produced by ionizing radiation and some chemotherapeutic drugs but also arise endogenously during DNA replication, by topoisomerase failure and as an initiator of physiological recombination processes like V(D)J recombination and meiosis.
Our research focusses the following objects:
In vivo formation and repair of DNA double-strand breaks after computed tomography examinations
Artemis and the ATM-dependent repair pathway: contribution in different phases of the cell cycle
Effects of very low doses of ionizing radiation Biological Effects of Space Radiation
Forschung & Lehre