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Universität Heidelberg - SFB 1036

Colloborative Research Center (SFB 1036) Cellular Surveillance and Damage Response

The long-term goal of this Collaborative Research Center (Sonderforschungsbereich, SFB) entitled "Cellular surveillance and damage control" is to elucidate the molecular mechanisms driving and coordinating damage control systems. In 17 research projects (TP) and 2 service projects (Z) the question of how the quality of gene function is monitored and how damage signals are integrated to elicit appropriate responses will be analyzed. This should provide a comprehensive understanding of how cells react to damage and establish and maintain homeostasis. Towards this goal the SFB will investigate:

Safeguarding systems that avert potential errors and damage by ensuring proper performance of cellular processes such as DNA replication, translation, and those underpinning homeostatic environments (e.g. iron homeostasis or redox state).

Damage repair systems which detect damaged or abnormal macromolecules (DNA, RNA, proteins) and provide repair and/or regulated elimination.

Stress response pathways that increase cellular capacity to cope with specific or global stress (e.g. heat shock, oxidative stress, protein overload in the endoplasmic reticulum). With the planned research on surveillance mechanisms and damage responses we are aiming at providing a comprehensive understanding of how cells react to damage and establish and maintain homeostasis.

Details


Adresse:
Universität Heidelberg - SFB 1036
Colloborative Research Center (SFB 1036) Cellular Surveillance and Damage Response
Im Neuenheimer Feld 282
69120 Heidelberg
Deutschland
Arbeitsgebiet:
Forschung & Lehre
Expansion:
national
Gründungsjahr:
2012