Universität zu Köln
The Goals of the Collaborative Research Centre 829 (SFB 829) are ...
To understand how molecular and cellular interactions within and between the different skin compartments are established and maintained to ensure homeostasis and to understand the key pathways by which challenges disturbing this communication cause skin disease.
To achieve this overall goal the following questions will be addressed at a molecular level:
1.How do skin cells interact and communicate with each other (similar and different cell types)?
2.How does contact of skin cells with the extracellular matrix modulate communication?
3.With are the crucial signalling pathways used for communication?
4.How does disturbance of key pathways affect skin homeostasis and how does this result in disease?
Our overall aim is (1) to identify key communication pathways for cellular interactions in the skin, which serve to maintain tissue homeostasis, and (2) to define the role of these pathways in disease processes.
In the long term this will allow to translate molecular mechanisms regulating skin homeostasis snd skin disease to the design of novel therapeutic strategies.
To address these questions we have selected two sets of projects:
1.Research area A: Epithelial cell function
2.Research area B: Non-epithelial cell function
Research area A (Epithelial cell function) consists of 9 projects and focuses on epithelial cells and their role in the regulation of cell-cell and cell-extracellular matrix interactions, repair and regeneration, skin immune responses, as well as development and maintenance of epidermalstructures (including skin appendages) and barrier function in normal and pathological situations.
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Forschung & Lehre