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University of Geneva, Switzerland

Department of Cell Biology, Faculty of Sciences

We are an international team of ca. 10 members (graduate students, post-docs and technicians). Our research focuses on the splicing of mRNA-precursors (pre-mRNAs), which is essential for proper gene expression. Introns (non-coding regions) must be spliced out of a pre-mRNA and exons (coding regions) ligated to make mature mRNA. Many mutations that affect the splicing process cause disease, demonstrating that splicing is important for normal cellular function. More than 60% of human pre-mRNAs are spliced in an alternative fashion and the resulting mRNAs encode proteins with distinct functions. Alternative splicing therefore increases the coding capacity of the human genome and permits the production of more than 100,000 proteins from only 25,000 genes. We are studying proteins and ribonucleoprotein particles that function at the onset of splicing with molecular and cell biology approaches.

Details


Adresse:
University of Geneva, Switzerland
Department of Cell Biology, Faculty of Sciences
Sciences III, quai Ernest-Ansermet 30
CH-1211
Deutschland
Arbeitsgebiet:
Forschung & Entwicklung
Forschung & Lehre
Expansion:
international
Gründungsjahr:
1992