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PhD studentship: Reconstructing the regulatory networks of integrin trafficking

im Bereich Forschung & Entwicklung, Wissenschaftl. MitarbeiterIn
bei Universität Heidelberg, AG Prof. Russell Proteinevolution / CellNetworks

The cluster of excellence CellNetworks at Heidelberg University unites more than 90 leading research groups from the University (faculties of Medical Science, Bioscience and Natural Science) and internationally outstanding research institutions (EUROPEAN MOLECULAR BIOLOGY LAB, GERMANY CANCER RESEARCH CENTER, MAX PLANCK CENTER FOR MEDICAL RESEARCH and the CENTRAL INSTITUTE FOR MENTAL HEALTH) in one common objective: Explore complex networks within and beyond the cell, describe functional interaction in unprecedented detail and truly understand how it all fits into place.

In the framework of a new interdisciplinary initiative on Reconstructing the regulatory networks of integrin trafficking, CellNetworks has the following vacancies for three PhD studentships in Biophysics, Molecular/Cell Biology and Bioinformatics.

Integrins are the main receptors for cell-matrix adhesion and are continuously trafficked within the cell. An exact understanding of the cellular networks regulating integrin trafficking is missing, but is crucial for clarifying how cells respond to adhesive clues in their environment and thus for understanding many vital processes, including cell migration or virus uptake. We will combine here methods from cell and molecular biology, systems biology, theoretical biophysics and bioinformatics to reconstruct the cellular networks regulating integrin trafficking. Reconstructing the integrin internalization network is a big challenge , because, in contrast to the internalization of other cargoes, integrins take diverse routes, depending on their ligand, activation state, organization of adhesion structures and the cytoskeleton. In order to meet this challenge, our project will combine recent advances in four different fields:
1) micropatterned substrates to control the spatial arrangement of adhesion structures and the cytoskeleton as well as to constrain trafficking processes spatially;
2) RNAi to identify the relevant molecular players;
3) biophysical models relating the organization of the adhesion structures and the cytoskeleton to the trafficking processes and vice versa;
4) computational network reconstruction techniques developed in bioinformatics.

We offer a highly stimulating and international research environment at CellNetworks. All three PhD-students will work in the BioQuant-building in the science campus Im Neuenheimer Feld. Further information on CellNetworks and details of its research areas can be found at: www.cellnetworks.uni-heidelberg.de.

Applicants should indicate the research area they are applying for and send a detailed CV including a short summary of their research experiences and interests, copies of certificates as well as the name and contact details of two referees, by e-mail as a single PDF file no later than August 31, 2010 to:


1) Dr. Vytaute Starkuviene-Erfle
Viroquant, Im Neuenheimer Feld 267, 69120 Heidelberg
Email: vytaute.starkuviene@bioquant.uni-heidelberg.de
Tel. +49 6221 54 51 259

2) Prof. Dr. Ulrich Schwarz
Institute for Theoretical Physics
Philosophenweg 19, 69120 Heidelberg
Email ulrich.schwarz@bioquant.uni-heidelberg.de
Tel. +49 6221 54 9431

3) Prof. Dr. Rob Russell
CellNetworks, Im Neuenheimer Feld 267, 69120 Heidelberg,
Email: yvonne.lara@bioquant.uni-heidelberg.de
Tel. +49 6221 54 513 61

Heidelberg University is an Equal Opportunity Employer and strongly encourages female candidates and handicapped persons to apply.