ImmunoSensation is a Cluster of Excellence funded by Germany’s Excellence Strategy at the University of Bonn. Participating scientists are dedicated to investigating innate immunity beyond the boundaries of classical immunology. In a joint effort, immunologists, neuro-biologists, systems biologists and mathematicians of the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE) of the Helmholtz Association aim to connect the status of the immune system, the metabolism and the nervous system to disease states. ImmunoSensation is embedded into the outstanding research environment of the University of Bonn, the University Hospital Bonn and the DZNE. Furthermore, ImmunoSensation is internationally connected and maintains research partnerships with Australia (Melbourne University), Japan (Osaka University, Waseda University, Kyoto University) and the Netherlands (Radboud University, Nijmegen).