Molecular Bioenergetics Group -
Radboud Institute for Molecular Life Sciences, Radboudumc

 Nijmegen
Our research interest focuses on the structure and function of respiratory chain complexes. We established the strictly aerobic yeast Yarrowia lipolytica as a powerful model to study mitochondrial complex I leading to a series of discoveries especially on the ubiquinone and inhibitor binding domain. In recent years we published the X-ray structure of this giant membrane integral multiprotein complex shedding light on the still enigmatic molecular mechanism of energy conversion by this redox driven proton pump.  In 2012 our group established complexome profiling and we have now developed it into a powerful proteomics approach to study the composition and dynamics of multiprotein complexes. This allowed deciphering the pathway by which the 44 different subunits of mitochondrial complex I are assembled and led to the discovery of several assembly factors supporting this process. We have also studied numerous other aspects of mitochondria biology bridging classical bioenergetics and the exciting recent developments that featuring mitochondria as key players in apoptosis, degenerative disorders and ageing. 

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Fakten

Expansion: international

In unserem Unternehmen arbeiten Mitarbeiter in diesen Arbeitsgebieten:
Forschung & Lehre, Wissenschaftliche/r Mitarbeiter/in

In unserem Unternehmen arbeiten Mitarbeiter mit den folgenden fachlichen Qualifikationsprofilen:
Pharma, Biologie & Life Sciences, Chemie, Humanmedizin

Standort

Molecular Bioenergetics Group
Radboud Institute for Molecular Life Sciences, Radboudumc
Geert Grooteplein-Zuid 10
Department of Pediatrics, Route 772
6500GA Nijmegen
Niederlande