Cell Biologist (f/m/d) (Post-doc position)

The IUF – Leibniz Research Institute for Environmental Medicine investigates the molecular mechanisms through which particles, radiation and environmental chemicals harm human health. The main working areas are environmentally induced aging of the pulmonary system and the skin as well as disturbances of the nervous and immune system. Through development of novel model systems the IUF contributes to the improvement of risk assessment and the identification of novel strategies for the prevention / therapy of environmentally induced health damage. The core unit model development is offering a position for a
Cell Biologist (f/m/d) (Post-doc position).


The position is to be filled at IUF as of January 1st, 2020.
The project is focused on the potential risk of environmental toxicants including particles, Chemicals and radiation)
  • Generation and validation of human pluripotent stem cells (hPSCs) from human somatic cells including those coming from patients carrying mutations;
  • Development and validation of 3D culture systems including organoids from human induced pluripotent stem cells (iPSCs) and human embryonic stem cells (hESCs);
  • Generation of genetically engineered human cells and organoids by using CRISPR/Cas9 system of newly identified key regulators;
The project aims to the understanding of the underlying mechanisms and their genetic susceptibility involved in the development of pulmonary and brain disease associated with particle exposure. The candidate will work on improving various aspects of existing techniques as well as developing novel models for the investigation of lung pathogenesis after particle exposure and generation of genetically modified human lung cells and organoids.

Activities and responsibilities

ROLE RESPONSIBILITIES
  • The individual should apply their significant expertise in cell biology, cell culture and organoids, molecular biology based techniques, along with their understanding such as plasmid cloning, gene editing, AAV vector production, electroporation, qPCR, RT-PCR, nucleic acid extraction and cloning, gel electrophoresis, macromolecule blotting and probing and mouse handling is highly desirable.
  • Participate in the development and qualification of assays. Independently analyze data and provide conclusions. Critically evaluate own and others results and offer insights based on process and product understanding to help solve problems.
  • Contribute to patents, regulatory documents or manuscript as required.
  • Read scientific and technical literature in order to bring new and improved procedures to the laboratory, and to broaden understanding of disciplines outside area of training. Utilizes all appropriate experimental design methods needed for work in area of specialization. Conduct literature searches and apply knowledge to the approaches taken.
  • Participate in scientific discussion with colleagues through informal and formal scientific seminars and meetings.

Qualification profile

Qualifications

We seek a highly motivated candidate (f/m) with a solid background in cell biology. Expertise in standard molecular biology techniques, cell culture and ex-vivo models is critical. Previous work with lung models is a plus. The candidate is required to have strong skills in English and German and proven abilities to publish at a high international level with at least one first author publication. Motivation to work independently and be responsible for the daily management of his/her research project in coordination with other members of the group is expected. The candidate will also be actively involved in the training and co-supervision of other group members and students.

EDUCATION AND EXPERIENCE
  • Ph.D. in Molecular Biology, Biology, Physiology, Biochemistry, or related field.
  • Minimum 3 years of experience with cell culture, iPSC cells, ex-vivo models and organoids.
  • Understanding of brain and lung physiology, cell types and co-culture systems is highly appreciated.
  • Demonstrated competency in immunohistochemistry, western blotting and DNA cloning.
  • Demonstrated proficiency in Microsoft Office, including Word, Excel, and PowerPoint.
  • Strong verbal and written communication skills are required (English and German).

DESIRED KEY COMPETENCIES
  • Self-motivated, highly organized, meticulous hands-on habits, keen to accuracy, and attention to detail.
  • Positive can-do attitude, responsible and responsive, and maintain a high degree of ethical standard and trustworthiness.
  • Strong quantitative and analytical skills, able to reach rational conclusions through complex processing of information.
  • Energized by accomplishments and excellence in the workplace. Competent of high performance in independent work and coordinated efforts in implementing group projects.
  • Maintain timely documentation of laboratory work and keep well organized records.
  • Evaluate results, analyze and interpret data to prepare projects updates, meeting presentations and research reports for documentation and publication.

We offer

The position is limited for to 2 years with the option of a permanent position. The weekly working time totals 39 hours and 50 minutes. Remuneration is given in accordance with the provisions of the collective agreement for the employees of the states (TV-L). Salary will be according to TV-L (E13).
Please address your application (incl. letter of motivation, CV, references, qualification certificates), preferably electronically, to:
Dr. Andrea Rossi
IUF – Leibniz-Institut für umweltmedizinische Forschung
c/o Personalstelle
Auf’m Hennekamp 50
40225 Düsseldorf
Bewerbung@IUF-Duesseldorf.de
Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.

Send application to

Dr. Andrea Rossi
IUF – Leibniz-Institut für umweltmedizinische Forschung
c/o Personalstelle
Auf’m Hennekamp 50
40225 Düsseldorf
Bewerbung@IUF-Duesseldorf.de

While applying for the job please refer to jobvector and use the following reference number: Cell Biology

About IUF - Leibniz Institut für umweltmedizinische Forschung gGmbH

Die zentrale Aufgabe des Instituts für Umweltmedizinische Forschung (IUF) ist molekulare präventivmedizinische Erforschung umweltinduzierter Erkrankungen. Das IUF widmet sich mit einer Vielzahl von Forschungsarbeiten den biologischen Wirkungen, die Umweltschadstoffe (insbesondere Partikel und nicht-ionisierende Strahlung) auf den menschlichen Organismus ausüben.
More about IUF - Leibniz Institut für umweltmedizinische Forschung gGmbH