The Comprehensive Heart Failure Center Würzburg (CHFC) is an
Integrated Research and Treatment Center supported by the German
Ministry of Education and Research. More than 120 scientists conduct
interdisciplinary basic, translational, and clinical research and provide
innovative patient care in the field of prevention of heart failure and its
medical complications. The CHFC's vision is to improve the awareness of
heart failure as an urgent health challenge in society, to connect existing
excellent basic science and clinical research and to implement preventive
strategies for diagnostics and management as well as new therapies. In
2017, the CHFC moved into a modern research building comprising four
departments, i.e. imaging, translational research, genetics, and clinical
research.

Activities and responsibilities

PhD Student (f/m/g)in the field of Experimental Heart Failure Research
The Department of Translational Research investigates the molecular
mechanisms of heart failure to identify potential therapies to prevent or
ameliorate the disease. The department has a strong focus on how
changes in the cardiac metabolism contribute to the development of the
disease. Mitochondrial metabolism covers the energy demand of cardiac
tissue and mitochondrial dysfunctions often manifest themselves as
cardiac diseases. We are interested in the pathological mechanisms how
mitochondrial dysfunctions cause defects in cellular respiration,
production of reactive oxygen species and alterations in metabolic
substrate fluxes.

Qualification profile

As the immune system also plays an important role in cardiac remodeling,
we are also interested in the central role of the metabolism during
immune cell activation. We use mouse models, patient iPSC-derived
cardiomyocytes, primary cell cultures and cell lines as model systems. To
analyze changes in metabolism and the function of cardiomyocytes, we use
a large set of techniques including methods of cell biology, biochemistry,
and molecular biology (Dudek et al., Stem Cell Res., 2013; Dudek et al.,
EMBO Mol. Med., 2015, and Chowdhury et al., Cell Reports, 2018). For
further information on the scientific activities at the CHFC, please see our
website: www.ukw.de/research/research-comprehensive-heart-failurecenter-
chfc/further-research-groups/ag-dudek or contact
dudek_j@ukw.de
We are looking for a highly motivated candidate with a masters degree in
life sciences (biology, biochemistry or equivalent) and a good
understanding of cell biology, biochemistry and molecular biology. The
applicant will join the Graduate School of Life Sciences, an innovative PhD
training program, which brings together junior researchers from different
areas of research. Interest to work with mouse models is essential.

We offer

Applications containing a cover letter explaining relevant experience and
interest, CV, copies of final certificates and contact details of two referees
should be sent preferably via email (all together in one single PDF
document) to: dzhi@ukw.de.
Payment is based on a fixed-term work contract and will be according to
the TV-L. Disabled applicants will be considered preferentially in case of
equivalent qualifications.
Comprehensive Heart Failure Center,
Am Schwarzenberg 15 · Haus A15 · 97078 Würzburg
For further information please visit www.dzhi.de.

Send application to

Comprehensive Heart Failure Center,
Am Schwarzenberg 15 · Haus A15 · 97078 Würzburg
For further information please visit www.dzhi.de

While applying for the job please refer to jobvector and use the following reference number: PhD-AG-Dudek-DZHI-Würzburg

About Universitätsklinikum Würzburg

Das Deutsche Zentrum für Herzinsuffizienz Würzburg (DZHI) erforscht als integriertes Forschungs- und Behandlungszentrum die Grundlagen der Herzinsuffizienz und entwickelt innovative Konzepte zur Behandlung dieser weit verbreiteten Erkrankung. Der neue multidisziplinäre Ansatz des DZHI bietet ein gleichermaßen attraktives Umfeld für klinische Spitzenforschung und...
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