PhD Thesis in cancer research: Induction of genome aberrations and tumor evolution by oncogenic signaling pathways.

Structural and numerical genome aberrations represent THE hallmark of human cancer contributing to the evolution of tumors into aggressive and metastatic forms. One the most prevalent form of genome alterations is the induction of aneuploidy, which is due to errors during mitotic cell division. However, the molecular mechanisms of how this form of chromosomal instability (CIN) is induced remains largely unknown.

We are investigating the molecular mechanisms of abnormal chromosome segregation during mitosis that causes the induction of aneuploidy in human cancer cells and we are highly interested in the role of oncogenic pathways that may play a key role in this context. We want to understand how abnormal oncogenic signaling pathways can contribute to defects in mitosis, chromosome missegregation, aneuploidy and thus, to tumor evolution.

Example publications (PDFs upon request available):
Stolz et al., Nature Cell Biology 2010
Ertych et al., Nature Cell Biology 2014
Ertych et al., PNAS 2016
Böhly et al., Cell Cycle 2019

Activities and responsibilities

We are looking for a highly motivated PhD candidate (m/f) with interest in cancer research, cell biology and cell cycle and mitosis research. The candidate will have the chance to focus on an own research project directed to the analyses of oncogenic signaling pathways during the cell cycle and during mitosis.

Qualification profile

The candidate should hold a very good Master degree in Molecular Biology, Molecular Medicine, Human Biology, Biology, Biochemistry or similar. Experience in handling human tissue cultures, in transfection methods, in microscopy and knowledge in signal transduction would be a plus.

We offer

The planed investigations will involve the use of various human cell systems, state-of-the-art cell biological and molecular biology methods including live cell microscopy (DeltaVision microscope), cell cycle analyses (FACS), fluorescence microscopy, cell manipulations with siRNA and CRISPR/Cas etc.

We offer to participate in our recently established research consortia focussing on genome alterations in human cancer. This will provide opportunities for various interdisciplinary collaborations (see e.g.: www.for2800.de or www.sfb1324.de).

The PhD candidate will also have the chance to participate in one of the structured graduate programs in Göttingen, which will provide method and soft skill courses and additional benefits for a successful PhD thesis work. We offer a highly stimulating scientific environment, lab space with state-of-the-art equipment (e.g. including live cell microscopy), an optimal supervision and support and opportunities for collaborations within the framework or research consortia.

Links:
www.for2800.de
www.sfb1324.de
http://www.moloncol.med.uni-goettingen.de/de/content/researchgroups/101.html

Send application to

Please send your full application including CV, description of your lab experience, a letter of motivation, copies of bachelor and master certificates, list of publications and the names and addresses of two references as a single pdf file to:
holger.bastians@uni-goettingen.de

While applying for the job please refer to jobvector and use the following reference number: 13022020

About Göttinger Zentrum für Molekulare Biowissenschaften (GZMB)

Arbeitsgruppe "Zelluläre Onkologie": Wir sind ein grundlagenwissenschaftliches Labor der Georg-August Universität in Göttingen. Wir sind Teil des Universitätsklinilums (UMG) und des Göttinger Zentrums für Molekulare Biowissenschaften (GZMB). Unser Forschungsfeld beinhaltet die molekulare Analyse des Zellzyklus und der chromosomalen Instabilität in Tumorzellen. Insbesondere sind wir an den...
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