Autophagy Regulation in Motor Neurons

Within the project “Regulation of synaptic autophagy in motoneurons and its implication in motoneuron disease“, the Institute of Clinical Neurobiology (University Hospital Würzburg) invites applications for a PhD student.

We are interested in the molecular mechanisms of motoneuron disease, with a focus on signaling pathways regulating cytoskeletal dynamics, presynaptic function, and axonal autophagy.

Activities and responsibilities

As part of this research project, we would like to study the regulation of synaptic vesicle autophagy in motoneurons and its application in motoneuron disease. Using different transgenic and knockout mice (i.g. reporter mice and models of ALS) the impact of neuronal activity on synaptic autophagy will be studied. As a readout, the autophagy pathway will be analyzed by expression of reporter constructs, immunohistochemical stainings, electron microscopy, and Western blotting.

For further information, see publications from our group:

https://www.nature.com/articles/s41467-017-00689-z
https://www.sciencedirect.com/science/article/abs/pii/S0959438817303185?via%3Dihub

Qualification profile

We are looking for a highly motivated PhD student with knowledge in cell- and/or neurobiology and a technical background in histology (tissue processing) and confocal microscopy. The candidate will analyze the motor performance of different mouse lines, and characterize alterations of the autophagy pathway by Western blot, immunohistochemistry, and high-resolution microscopy.

We offer

The project profits from strong cooperation and knowledge transfer between partner groups and is well be embedded in the research focus of the institute. He/she will have access to a modern and well-equipped research facility, will work with already available mouse lines, and will be supported by technical assistance.

Send application to

Applications including the usual documents (CV, certificates, brief statement of research interest, two references) should be sent as a single pdf file to Lueningsch_P@ukw.de.

While applying for the job please refer to jobvector

About Institut für Klinische Neurobiologie

The Institute of Clinical Neurobiology provides an attractive and international environment for clinical relevant cutting edge research. We are interested in the molecular mechanisms of motor neuron disease, with a focus on signaling pathways controlling cytoskeletal dynamics, presynaptic function, and the regulation of axonal autophagy.
More about Institut für Klinische Neurobiologie