PhD position in redox regulation of mitochondrial protein import and function

THE ENVIRONMENT: The Riemer Group (http://riemerlab.uni-koeln.de/) is part of the Institute for Biochemistry at the University of Cologne. Cologne is a vibrant city with a rich and dynamic cultural life. The University of Cologne is situated very close to the city centre and has a strong life sciences focus.

Research in the Riemer laboratory focuses on different aspects of redox and mitochondrial biology. For example, we characterize the mechanisms of disulphide formation and hydrogen peroxide signalling in different cellular compartments. We are also interested in the physiological impacts of these processes for example in calcium and in metabolic signalling (Suzuki et al, Nature Comm. 2013, Petrungaro et al, Cell Metabolism, 2015, Habich et al, Cell Reports, 2019 and Calabrese et al, EMBO J, 2019). To this end, we work with yeast and mammalian cells as well as purified proteins as model systems and apply a wide variety of biochemical, cell biological and biophysical approaches.

Activities and responsibilities

THE PROJECT: We extensively characterized the machinery for mitochondrial disulphide formation, the mitochondrial disulphide relay in human cells (Petrungaro et al, Cell Metabolism, 2015, Erdogan et al, Redox Biology 2018, Habich et al, Cell Reports, 2019). We want to extend on this work by characterizing a central component of this machinery, the protein ALR. ALR is involved in diverse metabolic processes (and not only disulphide formation) and appears to play a so far poorly understood role in liver regeneration. The project will include work with purified proteins, in cell culture and mice.

Qualification profile

WHAT YOU SHOULD BRING ALONG: First and foremost, you should bring along enthusiasm for science, curiosity, the drive to push a project to a successful ending and the willingness for teamwork. You should hold a Master’s degree in biology, biochemistry or another subject with a molecular life science background. During your Bachelor and Master studies, you should have demonstrated excellent performance. Experience with cell culture work and biochemical experiments is appreciated; knowledge of redox biochemistry is not required.

We offer

WHAT WE OFFER: We offer an exciting project, and extensive training in different experimental techniques and concepts. We offer a competitive salary (according to the German TvL scale, 65% E13). The laboratory language in our international team is English (i.e. knowledge of German is not required). The PhD position is available from January 2020 or upon mutual agreement.

Send application to

Jan Riemer

While applying for the job please refer to jobvector and use the following reference number: jr2020

About University of Cologne

The University of Cologne is one of the leading German research universities. It offers students an exceptionally broad and diverse subject base and encourages them to follow their own academic interests. This allows them to develop both intellectually and personally. The University is firmly committed to the advancement of human knowledge through basic research, but with an eye to transfer and...
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