PhD Position in The role of the SCN clock in the regulation of leptin signaling in the brain

The Graduiertenkolleg 1957 “Adipocyte-Brain Crosstalk” was established in 2014 with the funding from the German Research Foundation. It aims at providing structured doctoral training at the interface of neuroscience, biology and translational medicine. The DFG-funded Graduiertenkolleg 1957 “Adipocyte-Brain Crosstalk” studies the effects of adipose tissue hormones on CNS function and, in turn, the control of adipose tissue physiology by the brain. We are looking for highly motivated candidates for the following PhD project (supervisors in brackets). Tentative start: May 2020. Earlier start date from January 2020 could be discussed with the PIs in the interview.

Activities and responsibilities

Supervisor: Prof. Henrik Oster, Institute of Neurobiology

Project Description:


In mammals, a master circadian clock in the suprachiasmatic nucleus (SCN) synchronizes different central and peripheral tissue clocks to organize physiology and behavior across the 24-h day cycle. The adipokine hormone leptin is a major regulator of appetite and energy expenditure, acting via hypothalamic circuits. In obesity the brain becomes leptin resistant while at the same time circadian rhythms become disrupted. We hypothesize that circadian coordination of SCN-derived and feeding state-related signals determines the efficiency of leptin signaling to the brain, thus shielding the brain from a loss of leptin sensitivity and preserving its weight-controlling function under high-fat diet conditions.

Experimental Methods:
  • Working with genetically modified mice (knock-out mice), including breeding strategies
  • Phenotyping of mice including measurement of sleep-wake behavior, food intake, thermogenesis, energy expenditure and body weight
  • Organotypic slice cultures with long-term luminescence recordings
  • Immunohistochemical analyses
  • DNA and RNA extraction
  • PCR, qPCR, in-situ hybridization
https://www.grk1957.uni-luebeck.de/research/3rd-generation-projects/the-role-of-the-scn-clock-in-the-regulation-of-leptin-signaling-in-the-brain.html

Qualification profile

  • Research-based master’s degree or equivalent (e.g. diploma) passed with an above-average grade in neuroscience, biology, biochemistry, molecular life science, nutrition & biomedicine, pharmacology or a related subject (if you are working on the master thesis and expect to graduate until end of 2019/beginning of 2020, you can still apply - please state it in your motivation letter and upload the transcript to date)
  • Excellent English language skills in speaking and writing
  • Pro-active attitude, good communication skills and ability to work independently in an interdisciplinary team

We offer

  • 3-year employment contract, salaries according to German civil service tariff (TV-L 13, 65%)
  • All research groups are located at the Center of Brain, Behavior and Metabolism (CBBM) with state-of-the-art lab facilities incl. MRT scanner, metabolic core unit, LC-MS, microscopy
  • Comprehensive academic support, e.g. project-specific courses, soft skills training, funding for research stays abroad and international conferences, individual career coaching
  • Relaxed life style in city of Lübeck among many UNESCO World Heritage sites and directly on the Baltic Sea coastline and part of the Metropolitan area of Hamburg, Germany's second largest city and home to a wide range of cultural and leisure attractions

Send application to

Application deadline: 30.10.2019

https://www.grk1957.uni-luebeck.de/grk-1957/application-form.html

The complete application should include
  • a letter of motivation
  • a detailed CV
  • master's degree certificate AND transcript
  • a summary of the master thesis
  • bachelor's degree certificate AND transcript
  • two letters of recommendation (if you do not have the letters immediately available, please give us the contact details of two referees)
Documents issued in a language other than English or German must be translated into English AND certified by a public notary/German Consulate with an official seal.

While applying for the job please refer to jobvector

About University of Lübeck

Welcome at the GRK1957 "Adipocyte-Brain Crosstalk"Our DFG funded  Graduiertenkolleg 1957  offers focused research projects and a structured training programme. In an interdisciplinary research approach we address the effects of hormones derived from adipose tissue (adipokines) on CNS function and, in turn, the control of adipose tissue and body weight by the brain. ...
More about University of Lübeck