PhD position (Biotechnology / Molecular biology): Antiviral virus particles

The Bioprocess Engineering Group at the Max Planck Institute for Dynamics of Complex Technical Systems offers a PhD position in the Molecular Biology team with following topic:

“Antiviral virus particles: generation and mode of action of influenza A virus-derived defective interfering particles”

Activities and responsibilities

We are looking for a biotechnologist to join a team of four highly motivated scientists working in the field of molecular virology, defective interfering particles and vaccine production. You should have a strong interest in molecular biology of viruses and animal cells to conduct a very interdisciplinary thesis merging molecular biology, virology, complex analytics and bioprocess engineering. One of the major research aims of the Bioprocess Engineering Group is the optimization of influenza vaccine manufacturing in bioreactors using animal cells. From this work, a high impact project evolved that considers virus-derived defective interfering particles (DIPs) for use as antiviral agents. These are urgently needed, as many viruses are developing resistances against current chemical compounds.

We are therefore highly interested in the in-depth characterization of molecular biological aspects of virus replication and in the interfering mechanisms of such DIPs, and in establishing a production process. In the context of the PhD work, both basic and applied research shall be conducted. Specifically, existing technologies and measuring methods ought to be applied, new methods need to be established, and novel approaches for the efficient production of DIPs shall be developed.

Literature:
https://jvi.asm.org/content/88/10/5217.long
https://jvi.asm.org/content/93/4/e01786-18

Qualification profile

Requirements:
  • aboveaverage Master’s degree in biotechnology, biology, biochemistry, or similar
  • profound theoretical knowledge in molecular biology of animal cells and viruses
  • methodological competences (optional): cell culture, tissue engineering, realtime RT-qPCR, molecular cloning, transfection and transduction techniques, CRISPR/Cas9 and flow cytometry

We look for a highly motivated candidate with an interest in basic and applied research. Moreover, we expect a high level of self-initiative, an autonomous and conscientious working style, the ability to work in a team, and the ability to present the project and the results in an international environment in English.

We offer

We offer a position that involves a diversity of tasks in an interdisciplinary and intercultural research group, extensive training, direct and competent supervision, and state-of-the-art instrumentation and laboratory equipment. Collaborations with virology and tissue engineering groups are well established for additional support. The position is granted for three years with a salary based on the Collective Wage Agreement for Government Service Workers (TVÖD) and intended to conduct scientific research with the aim of acquiring a PhD. An extension is possible.

Send application to

Please submit your application documents (including a CV, employer’s / personal references, and copies of the Master’s and high school certificates) only via email to:
Prof. Dr.-Ing. Udo Reichl
sek-bpe@mpi-magdeburg.mpg.de

The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds.

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About Max Planck Institute for Dynamics of Complex Dynamical Systems

In 1996 the Max Planck Institute for Dynamics of Complex Technical Systems was established. The founding director is Prof. em. Dr.-Ing. Ernst Dieter Gilles. The institute in Magdeburg is the first institute of the Max Planck Society dedicated to the engineering sciences and is intended to bridge the gap between basic research and industrial applications. At present 240 employees are...
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