1 PhD position within the RTG 1976: Functional Diversity of Cofactors in Enzymes, University Freiburg

Research Training Group 1976: „Functional diversity of cofactors in enzymes” 

The University of Freiburg (Albert-Ludwigs-Universität) welcomes applications for PhD position for a three‐year structured program in the varied fields of the Research Training Group „Functional diversity of cofactors in enzymes” (RTG 1976, www.cofactor-diversity.uni-freiburg.de/RTG).
The Research Training Group focuses on the diversity of cofactors in enzymes with different projects reaching from enzymology and mechanism of cofactors and enzymes to their application in medicine and biotechnology.
Currently we have one open position for PhD students starting January 1st, 2019:
  • P10:  Synthesis and biochemical testing of inhibitors of histone deacetylases, specifically the NAD dependent deacetylase smSirt2 from Schistosoma mansoni.
We will work on the synthesis and biochemical in-vitro testing of inhibitors of histone deacetylases, specifically the NAD dependent deacetylase smSirt2 from Schistosoma mansoni. The assays will involve established fluorescence based in-vitro assays using acetylated, but also long-chain acylated substrates previously synthesized and characterized in our group. We have already identified small molecule hits for inhibition of smSirt2 and established the synthesis. Now we aim to perform bio-guided optimization in feedback loop using medicinal chemistry, biochemistry and anti-parasitic testing (the latter by collaborators). We also aim to establish Proteolysis targeting chimeras (PROTACs) using prior knowledge on such protein degradation agents that we have obtained on human sirtuins.

The three‐year structured program consists of lecture series, PhD seminars, workshops, symposia and retreats. In addition, participants will have the possibility to attend courses for individual need. Successful candidates will be awarded the PhD degree (Dr. rer. nat.). The program is taught in English.

Requirements:
  • excellent graduates in the fields of pharmacy, chemistry, biology, biochemistry, biotechnology (Master or equivalent)
  • proven interest in one or more of the above indicated research fields
  • highly motivated and committed
  • interested in participating actively in the program of the RTG
  • very good written and spoken English skills 
The duration of the PhD position is limited to three years. The salary is in accordance with the German public service salary scale (TV‐L E13, 65%).  

The following documents are required for your application as PhD student:
  • a cover letter stating your interests and why you want to become part of the RTG, preference for one project and why you think you would fit into this project
  • your curriculum vitae
  • your degree certificates and study transcripts with a description of the grading scheme
  • an abstract (maximum 1 page) of your diploma or master thesis
  • a list of your publications, if available
  • addresses of two potential references and, if available, letters of recommendation
  • a tangible proof of your fluency in English, i.e. certificate (TOEFL, Cambridge certificate, IELTS); German “Abitur” is eligible as proof of fluency in English 
All documents should be provided in English.
Please submit the above-mentioned documents as one PDF file.
Interested candidates should send their application containing the required documents as one pdf file only to susanne.elfert@pharmazie.uni-freiburg.de. Applications will be considered until position is filled. Please refer to “Application RTG 1976-P10” in the subject line.

Activities and responsibilities

We will work on the synthesis and biochemical in-vitro testing of inhibitors of histone deacetylases, specifically the NAD dependent deacetylase smSirt2 from Schistosoma mansoni. The assays will involve established fluorescence based in-vitro assays using acetylated, but also long-chain acylated substrates previously synthesized and characterized in our group. We have already identified small molecule hits for inhibition of smSirt2 and established the synthesis. Now we aim to perform bio-guided optimization in feedback loop using medicinal chemistry, biochemistry and anti-parasitic testing (the latter by collaborators). We also aim to establish Proteolysis targeting chimeras (PROTACs) using prior knowledge on such protein degradation agents that we have obtained on human sirtuins.

Qualification profile

Requirements:
  • excellent graduates in the fields of pharmacy, chemistry, biology, biochemistry, biotechnology (Master or equivalent)
  • proven interest in one or more of the above indicated research fields
  • highly motivated and committed
  • interested in participating actively in the program of the RTG
  • very good written and spoken English skills 

Benefits

The three‐year structured program consists of lecture series, PhD seminars, workshops, symposia and retreats. In addition, participants will have the possibility to attend courses for individual need. Successful candidates will be awarded the PhD degree (Dr. rer. nat.). The program is taught in English.

Send application to

Dr. Susanne Elfert
wissenschaftliche Koordinatorin,
DFG Graduiertenkolleg 1976
Albert-Ludwigs-Universität Freiburg
Institut für Pharmazeutische Wissenschaften Lehrstuhl Pharmazeutische Biologie und Biotechnologie
Stefan-Meier-Str. 19 (VF)
79104 Freiburg im Breisgau
susanne.elfert@pharmazie.uni-freiburg.de
Tel. 0761-203-8370
www.cofactor-diversity.uni-freiburg.de
While applying for the job please refer to jobvector and use the following reference number: RTG 1976-P10

About Albert-Ludwigs-Universität Freiburg

The “Green City” Freiburg in southwestern Germany is known for its idyllic location on the edge of the Black Forest, its excellent recreational offerings, its high environmental standards, its vineyards, and of course its university. Founded in 1457, the University of Freiburg is situated in the heart of the city. The many national distinctions it has attained for its excellent research and...

More about Albert-Ludwigs-Universität Freiburg

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