PhD student (all genders) in Neuroimmunology

Ischemic stroke is a major cause of disability and mortality worldwide. In previous studies we have shown, that the inflammatory response in the ischemic brain is an important determinant for long-term stroke outcome. In this project, we will characterize the interplay of infiltrating CNS autoantigen-specific T cells with reactive brain-resident cells in stroke, and assess their functional consequences for the inflammatory post-ischemic tissue response and long-term regeneration. Understanding how antigen-specific T cells dictate the reactivity of brain-resident cells, and hence determine neuronal outcome during post-stroke inflammation will likely identify novel therapeutic targets enhancing neuronal survival and long-term recovery.
We will use a well-established preclinical murine model of ischemic stroke. Animal experimentation, advanced immunological, cell and molecular biological techniques, as well as bioinformatics will be applied. Essential methods are isolation of brain resident cells (i.e. microglia, astrocytes, neurons) and immune cells, flow cytometry, single-cell RNAseq analyses, tissue studies with spatial and multiplex techniques.

Your tasks:

• conception, execution, analysis and documentation of experiments, literature review, scientific writing and presentation

This project is funded by the Deutsche Forschungsgemeinschaft (DFG). The duration of employment is 3 years, with possibility for extension.

• Scientific university degree in biology, life sciences or comparable science (diploma, master, or equivalent)
• Sound immunological and cell biological skills and knowledge
• Preferably, immunological experience and FELASA course
• High interest in basic research, willingness to conduct animal experiments, ability to work independently as well as a part of an interdisciplinary research group
• Communication skills in English

Immunity status
Please note that employment is contingent upon proof of immunization or immunity against the measles virus, in accordance with applicable legal and medical requirements. Documentation (e.g., vaccination certificate) must be provided before employment begins.