Doktorarbeit - Gentherapie von Augenerkrankungen (Dr. rer. nat or PhD)

PhD Position (Dr. rer. nat or PhD)
 
Development of novel gene therapy vectors for the treatment of for inherited eye disorders

PhD Position at the
Department of Ophthalmology
Ludwig-Maximilians-Universität München
 
Scientific background. The group works on the development of recombinant adeno-associated virus (AAV) vector-based gene therapies for eye diseases and is part of the RD-CURE consortium (http://www.rd-cure.de) that successfully completed the first ocular gene therapy trial on CNGA3-linked achromatopsia (https://www.clinicaltrials.gov/ct2/show/NCT02610582) and currently prepares for the initiation of the first German retinitis pigmentosa gene therapy trial. AAV vectors have become the “gold standard” gene delivery tool for targeting retinal cells. AAV-based vectors have been tested in a number of human clinical trials and have proven safe for the use in the human eye. However, there is still unmet need for improvement of the AAV vector platform regarding tropism and transduction efficiency.

Further information:
www.pharmacology.cup.uni-muenchen.de/michalakiss/
www.cipsm.de/en/aboutCIPSM/members/michalakisStylianos/
http://www.lsm.bio.lmu.de/faculty/michalakis/index.html
www.gsn.uni-muenchen.de/people/research/biomed_ns/michalakis/
 
Please send your electronic application including a motivation letter, a full CV, transcripts and recommendation letters preferably as a single PDF.
 
How to apply:
A single PDF via Email.

Activities and responsibilities

Specific aims and methodology. The overarching goal of this project is the development of novel optimized AAV vector-based gene therapy vectors for gene-specific and/or gene independent treatment approaches. The novel vectors will be further developed for optimized efficacy in relevant animal models of inherited blinding diseases. The methodology will include state-of-the-art in vitro and in vivo biochemical, genetic, cell biological and viral gene transfer methods in relevant mouse models.

Qualification profile

A suitable candidates has a strong interest and background in at least one of the following fields: neurobiology, physiology,  anatomy (focus on the eye), molecular biology and gene therapy. A background in programming, statistics, and data analysis will be helpful.

We offer

We are a young, interdisciplinery and international group working on retinal gene therapy, neuroscience and epigenetics embedded in an excellent research environment and network at the Ludwig-Maximilians-University Munich.

Send application to

Prof. Dr. Stylianos Michalakis
Department of Ophthalmology
Ludwig-Maximilians-Universität München
Butenandtstr. 5-13, 81377 München
Email: michalakis@lmu.de

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