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PhD position - New Antiinfectives

The department/research group COPS of Prof. Dr. Ursula Bilitewski at the Helmholtz Centre for Infection Research in Braunschweig (Germany) is offering a
PhD position:  “New Antiinfectives”
Project description:
The increasing appearance of resistant bacterial pathogens requires the continuous search for new antiinfectives with new targets and, ideally, a probably reduced rate of resistance development.
To address new targets the knowledge about host – pathogen interactions should be exploited. As response to conditions in the host bacteria frequently express proteins, which allow survival and proliferation and which are virulence factors. Novel anti-infective strategies aim at the inhibition of either virulence factor expression or virulence factor activity. Thus, in this PhD project host - pathogen interactions will be mimicked by suitable in vitro cultivation conditions and cellular co-culture systems. Target pathogens will be Staphylococcus aureus and E. coli – strains. Suitable screening assays have to be established, which could be based either on the pathogen alone, but also on co-culture systems between host cells and bacteria. The physiological state of the pathogen in these conditions will be validated by appropriate analytical methods. Screening campaigns can use compound libraries comprising in total roughly 30000 small molecules. Identified active compounds will be developed further with respect to mode of action and SAR studies. State-of-the art bioanalytical methods are available for in-depth molecular analysis of the biological systems.
  • Master’s Degree/Diploma in Microbiology, Biochemistry, Biotechnology, Chemical Biology or a related field of the life sciences
  • Practical microbiological and cell culture experience, ideally with bacteria of BSL 2
  • Experience with bioanalytical techniques (e.g. protein analysis, qPCR)
  • Biochemical understanding of microbiological reactions
  • Excellent English communication skills (written and spoken)
  • Ability to work independently and as part of an international team
  • A strong desire to do research with high self-motivation and enthusiasm
With equal professional qualification, severely disabled persons will be prioritized.
Starting date: as soon as possible - Initial contract for 3 years –
Salary: TVöD E13 (65%) or research scholarship
Probation period: 6 months
Published: 04.05.2016

Closing date: 01.06.2016
Applicants are required to complete the online application form here: https://hzi.opencampus.net/ (Please refer to the job number 12/2016)
For questions regarding the PhD project, please contact Prof. Dr. Bilitewski via e-mail ursula.bilitewski@helmholtz-hzi.de or phone +49-531-6181-1010.

How to apply:
Applicants are required to complete the online application form here: https://hzi.opencampus.net/ (Please refer to the job number 12/2016)
Kontakt für Bewerbungen
Further information about the institute and the research group of Prof. Dr. Bilitewski can be found on our website: http://www.helmholtz-hzi.de/en/research/research_topics/anti_infectives/compound_profiling_und_screening/.
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: 12/2016

Über Helmholtz-Zentrum für Infektionsforschung GmbH

Helmholtz-Zentrum für Infektionsforschung. Wir konzentrieren uns auf Bakterien, die medizinisch relevant sind oder als Modell für die Erforschung von Infektionsmechanismen genutzt werden. Mit unserer Arbeit leisten wir einen nachhaltigen Beitrag für die Gesundheitsvorsorge.

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