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PhD Position: Proteome dynamics during exposure to mechanical stress

We are seeking a dedicated and creative PhD student for our protease degradomics and protein mass spectrometry team at ZEA-3 (Analytics) for a collaborative project with ICS-7 (Biomechanics) within the framework of the newly established DFG research unit FOR2743 “Mechanical Stress Protection”. Mechanical stress affects almost every cell in the human body, but the molecular mechanisms allowing cells to respond and adapt to these forces are still incompletely understood. This project aims to obtain a systems-level understanding of protein fate in cells exposed to controlled mechanical stress conditions, including changes in protein modifications, interactions, stability and turnover.

Your tasks:
  • Global proteome analysis, including sample preparation, data acquisition and evaluation.
  • Adaptation and development of protocols for proteome turnover measurements.
  • Contribution to mass spectrometry instrument operation and maintenance.
  • Cell biological experiments, including cell culture and application of mechanical stress.
Your profile:
  • Master´s degree in analytical chemistry, biochemistry, cell biology or a related field with a good final grade (equivalent to grade 2.0 or better in the German grade system).
  • Strong experience in life science laboratory skills (molecular & cellular biology, biochemistry).
  • Curious, motivated, reliable, aptitude for self-organized/independent work.
  • Strong communication skills in English (fluent).
  • Ideally previous hands-on experience in proteomics and/or proteomics data analysis.
Our offer:
  • A three-year PhD position (up to 65% EG 13), available from July 1st, 2018.
  • Scientific and transferrable skills courses.
  • Excellent experimental facilities at ZEA-3 (Analytics) and ICS-7 (Biomechanics).
  • Opportunities for external collaborations, particularly within FOR2743.
  • Supportive supervision and a highly collaborative and interdisciplinary team.
Forschungszentrum Jülich, located in proximity to the vibrant cities Aachen, Cologne and Düsseldorf in the West of Germany, is one of Europe’s largest research centers with more than 5,500 employees and provides excellent experimental facilities in a dynamic multi-disciplinary environment.

Forschungszentrum Jülich aims to employ more women in this area and therefore particularly welcomes applications from women. We also welcome applications from disabled persons.

Interested? Please apply by email with a cover letter detailing your motivation, your CV with relevant documentation and two letters of recommendation as a single pdf document to

Dr. Pitter Huesgen (p.huesgen@fz-juelich.de)
Forschungszentrum Jülich
Central Institute of Engineering, Electronics and Analytics
Analytics (ZEA-3)

Applications will be considered immediately until the position is filled.
 
Kontakt für Bewerbungen
Dr. Pitter Huesgen (p.huesgen@fz-juelich.de)
Forschungszentrum Jülich
Central Institute of Engineering, Electronics and Analytics
Analytics (ZEA-3)
Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: D078/2018

Über Forschungszentrum Jülich GmbH

Das Forschungszentrum Jülich leistet als Mitglied der Helmholtz-Gemeinschaft wirksame Beiträge zur Lösung großer gesellschaftlicher Herausforderungen in den Bereichen Information, Energie und Bioökonomie. Es bearbeitet vielfältige Aufgaben im Forschungsmanagement und nutzt große, oft einzigartige wissenschaftliche Infrastrukturen. Arbeiten Sie zusammen mit rund 5.900 Kolleginnen und Kollegen...

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