PhD student for Cellular and Integrative Physiology

Institute of Cellular and Integrative Physiology - Heisenberg Group Subcellular Pathophysiology

Activities and responsibilities

  • Plan and conduct experiments and molecular biology studies
  • Animal experiments: immunization of mice, measurement of antibody titers, clinical and histological work (analysis of serum and urine, immunohistochemical and immunofluorescence stainigs, high-resolution confocal microscopy and STED microscopy)
Molecular biology: cell specific analysis of expression and activity of the proteasomal and lysosomal systems, Western blots, qPCR, immune precipitations, cell expressions

Qualification profile

  • University degree in molecular life science, biology, chemistry or biochemistry
  • Strong interest in scientific questions, especially in autoimmunity and proteine degradation
  • Willingness to perform animal experiments
  • Desirable: knowledge in FACS analysis, molecular biology, histological methods (immune fluorescence, confocal and high-resolution microscopy)
  • Skills in MS Office
  • Excellent knowledge of English and German
  • Capacity for teamwork and independence, dedication, flexibility, skills in organization

We offer

  • An innovative and family-friendly work environment
  • Working in a young and highly motivated team
  • Advanced training in the post graduate program of the Collaborative Research Center (Sonderforschungsbereich) 1192
  • Presentation of your scientific results at national and international meetings

Our group is investigating the role of protein degradation in glomerular cell (patho)physiology via the lysosomal and proteasomal systems, focussing on membranous nephropathy which is an antibody-mediated autoimmune disease and the most common cause of a nephrotic syndrome in adult patients (see Tomas, Beck et al., NEJM 2014; Tomas, Hoxha et al., JCI 2016, Tomas, Meyer-Schwesinger et al. JASN 2018, Radon, Czesla et al. KI 2018, Herwig, Skuza et al. JASN 2019, Reinicke, Laban et al. PNAS 2019, Meyer-Schwesinger, NatRevNephrol 2019).

We are searching for aPhD student for a project exploring the cell-specific role of protein degradation focussing on the ubiquitin proteasomal system and the deubiquiting enzyme UCH-L1. The project is embedded within our Heisenberg professorship, entitled „Altered protein degradation – a new pathogenic concept of podocyte injury“. It is aiming to establish the prognostic pathogenic impact of autoimmune antibodies against the deubiquitinating enzyme UCH-L1 in membranous nephropathy.

Our group is associated to the Collaborative Research Center (Sonderforschungsbereich) 1192 and is thus embedded in an outstanding scientific environment.

This position is temporary for 3 years with 65% of the weekly working time.

Send application to

Frau Professor Dr. med. Catherine Meyer-Schwesinger (c.meyer-schwesinger@uke.de) oder Claudia Kollien (ckollien@uke.de)

Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: 2019-636

Über Universitätsklinikum Hamburg-Eppendorf

Über uns Fortschritt prägen. Völlig neu denken. Uns neu erfinden. Wir sind das UKE. Die pulsierende Gesundheitsstadt inmitten von Hamburg. Wo so viel Energie in der Luft liegt und der Fortschritt den Takt angibt, ist kein Tag wie der andere. Über 11.000 Mitarbeiterinnen und Mitarbeiter mit sehr unterschiedlichen Aufgaben eint hier das gleiche Ziel: das Wohl des Menschen. Für dieses...
Mehr über Universitätsklinikum Hamburg-Eppendorf