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PhD Student Position

PhD Student Position
(65% German TV-L E13, m/f)

Hoppe Laboratory
Protein Homeostasis in Ageing and Disease
- Regulation of mitochondrial surveillance by the UPS -
CECAD-Cluster of Excellence in Ageing Research, University of Cologne
Institution information: CECAD Cologne Cluster of Excellence: Cellular Stress Responses in Ageing-Associated Diseases, CECAD Research Center, University of Cologne, Joseph-Stelzmann-Str. 26, D-50931 Cologne, Germany
Location: Cologne is a vibrant city with a highly international academic research environment. CECAD forms a focal point of ageing research in Europe bringing together researchers and clinicians at the University of Cologne with researchers at the new Max Planck Institute for Biology of Ageing in a unique research venture.
This position is immediately available within the Collaborative Research Centre 1218, funded by the German Research Foundation:
Summary: The available project focuses on regulation of mitochondrial surveillance by the UPS. Caenorhabditis elegans mutants with increased levels of reactive oxygen species (ROS) are limited in protein turnover, demonstrating that mitochondrial stress affects the ubiquitin/proteasome system (UPS). Intriguingly, related disease-causing mutations associated with mitochondrial failure provide similar proteolytic defects in humans. The central objective of our proposed research is to identify conserved mechanisms that coordinate mitochondrial metabolism and ubiquitin-dependent proteostasis in the context of cellular and organismal physiology.
Qualifications: Candidates should have a solid background in molecular biology and experience in cell biology, genetics or biochemistry. Applicants should have demonstrated outstanding performance through their undergraduate studies. Besides creativity, a strong ability for problem solving through analytical thinking combined with an enthusiasm for scientific research is highly desirable. Additionally, we expect good communication skills, fluent English and the ability for teamwork. The successful applicant will join an enthusiastic and collaborative group where a multidisciplinary approach is pursued.

For more information: http://www.hoppelab.uni-koeln.de

Selected Publications:
Franz, A., Ackermann, L. and Hoppe, T.  (2016). Ring of change: CDC48/p97 drives protein dynamics at chromatin. Front. Genet. 7, 73.
Franz, A., Kevei, É., and Hoppe, T. (2015). Double-edged alliance: mitochondrial surveillance by the UPS and autophagy. Curr. Opin. Cell Biol. 4, 37:18-27.
Segref, A., Kevei, É., Pokrzywa, W., Schmeisser, K., Mansfeld, J., Livnat-Levanon, N., Ensenauer, R., Glickman, M.H., Ristow, M., and Hoppe, T. (2014). Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metab.  19, 642-652.
Livnat-Levanon, N., Kevei, É., Kleifeld, O., Krutauz, D., Segref, A., Rinaldi, T., Erpapazoglou, Z., Cohen, M., Reis, N., Hoppe, T., Glickman M.H. (2014). Reversible 26S Proteasome disassembly upon mitochondrial stress. Cell Rep.  7, 1371-1380.
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T*, and Clausen, T (2013). Cell, 152, 183-95. (*co-corresponding author)

How to apply:
How to Apply: Please send your CV, letter of intent, names and addresses of three references to office-hoppe@uni-koeln.de
Kontakt für Bewerbungen
University of Cologne
Hoppe Laboratory
CECAD Research Center
University of Cologne
Joseph-Stelzmann-Str. 26
D-50931 Cologne
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Über Universität zu Köln

Institut für Genetik, Arbeitsgruppe Prof. Dr. Thorsten Hoppe CECAD Cluster of Excellence in Ageing Research Protein Homeostasis in Ageing and Disease

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