PhD student (E13 65%) “Protein Sulfhydration”

The Institute of Vascular Signalling, Center for Molecular Medicine at the Faculty of Medicine, Goethe University, is offering

a PhD student position (E13 65%) “Protein Sulfhydration”
(for a period of 3 years with initial review after 12 months)

within the framework of a German research foundation (SFB 1366)-funded project focused on determining the consequences of protein sulfhydration in cardiovascular physiology/pathophysiology (see Circulation. 2019;139:101-114).

The Institute for Vascular Signalling was established in 2008 within the framework of the Excellence Cluster Cardiopulmonary System (ECCPS). The institute belongs to the Centre of Molecular Medicine and forms part of the Vascular Research Centre Frankfurt.
Our research work focuses on the biology of the vascular wall and the factors that influence it during disease development. There is a particularly strong focus on the role of nitric oxide, cytochrome P450–derived lipid mediators and platelets/platelet-derived products. All of these projects have a translational biomedicine emphasis with the aim of improving current disease therapy.

Activities and responsibilities

  • Participation in a research project focusing on the regulation of the formation and the consequences of hydrogen sulfide formation and protein sulfhydration and their consequences on cell metabolism in different tissues under physiological and pathophysiological conditions in vitro and in vivo.
  • Collection of experimental data, analysis and documentation of the results and preparation of the material for publication.

Qualification profile

  • A completed, very good MSc in biology, biochemistry, biotechnology, molecular medicine or a related discipline.
  • Training in protein biochemistry, proteomics, post translational modifications etc.
  • Good self organization and team working abilities.
  • While German is not necessary, excellent English is required in both written and spoken language.

We offer

  • a thematic high-level project in an internationally recognized group, which is part of the Vascular Research Center Frankfurt (
  • Rooms, housed in a new research building, with modern facilities and analysis possibilities from integrative physiology to mass spectroscopy.
  • National and international networking - The Institute is part of the DFG Cluster of Excellence "Cardiopulmonary Institute" and the German Center for Cardiovascular Research (

Send application to

Applications with the usual documents (in a single PDF file) and the names and contact details of 3 referees should be submitted in electronic form until 15.08.2019 to Prof. Dr. I. Fleming (

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Über Klinikum der Johann Wolfgang Goethe-Universität

Das Institute for Vascular Signalling wurde 2008 als eine Einrichtung des Exzellenzclusters Kardio-Pulmonales System (ECCPS) gegründet. Es ist Bestandteil des Zentrums für Molekulare Medizin (ZMM) im Fachbereich Medizin der Goethe-Universität Frankfurt und außerdem Mitglied im Vascular Research Centre Frankfurt. Die Forschungsarbeit des Instituts konzentriert sich auf die Biologie der...
Mehr über Klinikum der Johann Wolfgang Goethe-Universität