PhD Thesis in cell biology: The role of wnt signaling in mitosis and chromosome segregation

As part of the collaborative research center 1324 (SFB1324, Project B03) “Mechanisms and functions of Wnt signaling“ we are offering a PhD student position focussing on the role of Wnt signaling in mitosis.

The Wnt pathway is a key signaling pathway regulating various aspects of cell physiology and also contributes to cancer. Wnt signaling can also regulate the cell cycle and more recently it became clear that Wnt signaling also affects the execution of mitosis and chromosome segregation. In fact, our work showed that loss of Wnt signaling results in chromosome missegregation and aneuploidy as seen in many cancer cells (see e.g.: Stolz et al. EMBO Reports 2015). However, the molecular mechanisms of how Wnt contributes to mitosis are not known and this importnat question will be at the center of the planned PhD project.

Activities and responsibilities

We are looking for a highly motivated and enthusiastic PhD candidate (m/f) with true interest in cell biology and cell cycle and mitosis research. The candidate will have the chance to fully focus on an own research program directed to the analyses of Wnt signaling in the cell cycle and in mitosis in human cells. Moreover, the candidate will become part of the SFB1324, which offers additional benefits and chances to collaborate with other research groups focussing on Wnt signaling at the universities of Heidelberg, Göttingen and Karlsruhe (see: www.sfb1324.de). In addition, opportunities for collaborations within the framework of our newly established DFG research group focussing on mitotic chromosome segregation are offered (see: www.for2800.de).

Qualification profile

The candidate should hold a very good Master degree in Molecular Biology, Molecular Medicine, Human Biology, Biology, Biochemistry or similar. Experience in handling human tissue cultures, in transfection methods, in microscopy and knowledge in signal transduction would be a plus.

We offer

The planned research project will involve the use of various human cell systems, state-of-the-art cell biological and molecular biology methods including live cell microscopy (DeltaVision microscope), cell cycle analyses (FACS), fluorescence microscopy, cell manipulations with siRNA and CRISPR/Cas etc.

The PhD candidate will participate in one of the structured graduate programs in Göttingen, which will provide method and soft skill courses and additional benefits for a successfull PhD thesis work. We offer a highly stimulating scientific environment, lab space with state-of-the-art equipment (e.g. including live cell microscopy), an optimal supervision and support and opportunities for collaborations within the SFB1324 and FOR2800 frameworks.

Further information:
www.sfb1324.de
www.for2800.de

Send application to

Please send your full application including CV, description of your lab experience, a letter of motivation, copies of bachelor and master certificates, list of publications and the names and addresses of two references as a single pdf file to:
holger.bastians@uni-goettingen.de


How to apply:
Please send your full application via email as a single pdf file to:
Prof. Dr. Holger Bastians
Email: holger.bastians@uni-goettingen.de

Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: 22112019

Über Göttinger Zentrum für Molekulare Biowissenschaften (GZMB)

Arbeitsgruppe "Zelluläre Onkologie": Wir sind ein grundlagenwissenschaftliches Labor der Georg-August Universität in Göttingen. Wir sind Teil des Universitätsklinilums (UMG) und des Göttinger Zentrums für Molekulare Biowissenschaften (GZMB). Unser Forschungsfeld beinhaltet die molekulare Analyse des Zellzyklus und der chromosomalen Instabilität in Tumorzellen. Insbesondere sind wir an den...
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