Research Assistant (doctoral student) in Synthetic Biology/Cell-Free Protein Expression (E13-TV-G-U, 65 % part time)

Goethe University Frankfurt am Main is one of the largest universities in Germany with about 48,000 students and 5,000 employees. In 1914 Goethe University was founded by citizens of Frankfurt and in 2008 again it became a foundation under public law. Goethe University offers a high degree of autonomy, modernity and a wide range of study programmes. As a full university Goethe University offers more than 100 courses of study within 16 faculties on 5 campuses and at the same time it has an excellent research strength. Goethe University intends to increase the percentage of women and therefore especially encourages women to apply. Severely handicapped persons with equal qualifications will be given preference.

Activities and responsibilities

The Institute of Biophysical Chemistry (IBPC) at the Goethe University Frankfurt/Main offers a research opportunity for the development of new applications of cell-free expression and nanoparticle technologies. The project covers the application of cell-free synthesized G-protein coupled receptors (GPCRs) inserted into nanoparticles in a variety of drug development approaches. New nanodelivery strategies for the functional transfer of recombinant GPCRs into membranes of living cells will furthermore be refined and applied. The position is part of the newly LOEWE funded research cluster GLUE with participation of the Universities of Marburg, Frankfurt and Darmstadt as well as of the Max-Planck Institute of heart and lung research in Bad Nauheim. The project is highly interactive and combines key technologies in synthetic biology and membrane protein research such as cell-free expression, nanoparticle technologies, lipid-protein interactions, ligand binding, single cell microscopy, nuclear magnetic resonance spectroscopy and native mass spectroscopy. The project will request close collaboration with other groups of the GLUE cluster. Successful candidates will have the opportunity to participate in the associated COST action “ERNEST” ( offering a variety of workshops and conferences in all topics of GPCR research.

Qualification profile

Applicants should hold a diploma or master in biology or biochemistry together with a sound background in molecular biology and in standard biochemical techniques. Experience with membrane proteins will be a clear advantage but is not mandatory.

We offer

Subject to the condition that the grant will be committed the position will start in January 2020 or later and is initially for 3 years with possibility of one year extension. The salary is based on the job characteristics of the collective agreement applicable to Goethe University (TV-G-U).

The IBPC is located at the biocenter of the Goethe-University Frankfurt (Campus Riedberg) which provides excellent facilities for cell-free protein production and membrane protein research. The Campus Riedberg is a dynamic centre for life sciences research with an international and highly interactive scientific community. The campus hosts several science clusters like the Centre of Membrane Proteomics and the Centre of Biomolecular Resonance ( We offer a stimulating, diverse and international research environment.

Send application to

Applications containing a detailed CV including abstracts of the diploma thesis, method profile and description of research experience and interests should be sent by email until 1st of December to:
Dr. Frank Bernhard Institute of Biophysical Chemistry, University of Frankfurt, 60438 Frankfurt, Germany, to the email address of Ms Sigrid Fachinger

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Über Johann Wolfgang Goethe-Universität Frankfurt/Main

Forschung/Lehre an universitären Einrichtungen. Forschungsgebiete: Strukturbiologie, hochauflösende NMR-Spektroskopie, Membranproteine, Signaltransduktion, Antibotikasynthetasen, in vivo NMR, Transkriptionsfaktoren
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