Scientist (f/m) for “Base Correction“ in Pluripotent Cells

Activities and responsibilities

In vitro disease models represent the earliest stage of wet-lab-based preclinical research. In oncology, traditional disease models comprise patient-derived systems. However, recent research has challenged the suitability of such classical models for chemo therapy prediction studies.  Alternative donor-derived in vitro disease models with elevated genetic circumscription are considered to putatively be more suitable for physiological relevant target discovery and therapy testing in high-throughput.

The Department of Preclinical Research at the Neurosurgical Clinical of the Heinrich-Heine University, Düsseldorf, Germany is looking for a motivated candidate to fill a position to develop targeted transformation strategies in pluripotent cells (particularly human induced pluripotent stem cells as well as human fetal-derived neural stem cells, summarized as pluripotent cells, PC). Specifically, the establishment of efficient base correction assays to introduce point mutations as physiological relevant onco-disease models is envisioned. The candidate will be guided on the technology level by international and national leading experts in base corrector technology including on-site visits, regular data discussion etc. The ultimate goal is to validate those based-corrected cell systems in terms of acquisition of pathophysiological relevant tumorigenicity as well as chemo therapy resistance profiles compared to classical disease models as well as to overexpression/gene KD-mediated PC-based disease models.

The position is funded through the High-tech Strategy of the Federal Ministry of Education and Research (BMBF,  https://www.validierungsfoerderung.de/validierungsprojekte/discover ) and thereafter through alternative sources (total of 3 years minimum, starting as of Jan 2019). Please send the concise application documents (incl. one scientific reference) as one PDF file per e-mail to ulf.kahlert@med.uni-duesseldorf.de . The candidate will be embedded in an interdisciplinary research team consisting of researches with medical and natural science background (see homepage of the clinic).

Selected references:
https://www.ncbi.nlm.nih.gov/pubmed/30089904
https://www.ncbi.nlm.nih.gov/pubmed/28991255
https://www.ncbi.nlm.nih.gov/pubmed/28529064
https://www.ncbi.nlm.nih.gov/pubmed/29849122

Qualification profile

National or international Master, or PhD degree or equivalent.

Benefits

Saralry-based job in part time (50%-65%).

Send application to

Dr. Ulf Kahlert
Preclinical Research
Clinic for Neurosurgery/ Klinik für Neurochirurgie
Heinrich-Heine Universität
Moorenstrasse 5
40225 Düsseldorf

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