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2 PhD Positions (65%, TV-L E13) at the Max Planck Institute of Biochemistry in the lab of Boris Pfander

Chromatin as limiting factor in the regulation of DNA repair pathway choice

The project
The stability of the genome is constantly challenged by DNA damage, which is recognized as a driving force in cancer development. DNA repair has to occur within the context of chromatin and chromatin acts both as a barrier and a regulator of DNA repair. We have recently shown for the repair of DNA double strand breaks (DSBs) by homologous recombination that chromatin can be in two states, which are either
permissive or restrictive for homologous recombination (Bantele et al. 2017, eLIFE).
In the context of the collaborative research cluster SFB1064, we aim (I) to characterize these two states (e.g. chromatin-associated factors, histone modifications, etc) in a systems biology approach. Moreover, we aim (II) to use an in vitro reconstituted system to identify the biochemical mechanism of specific chromatinassociated factors that promote or impede repair by homologous recombination. Since these factors determine which pathway is used for the repair of the DSB our findings will reveal how cells control DNA repair pathway choice. These projects will therefore not only give fundamental insights into a basic cell biological mechanism, but also have a critical impact on future gene editing approaches (e.g. CRISPR/Cas9).

Your Profile
• recent degree (MSc or equivalent) in Biochemistry, Biology or a related discipline of the Life Sciences
• very high interest in basic cell biology
• independent worker
• strong commitment and work ethic
• strong background in lab techniques (project I – molecular cell biology; project II – biochemistry)
• high interested in interdisciplinary approaches
• open for international cooperation

We offer
• an internationally competitive PhD project in a young, ambitious and successful research team
• world-leading facilities and experimental support at the Max Planck Institute of Biochemistry
• productive collaborations within the Research Cluster ‘Chromatin Dynamics’ and with international experts in the field of genome stability
• plentiful opportunities to further develop professional skills within a multi-disciplinary research team
• a 3-4 year structured PhD program (IRTG) with possible additional courses at the Max Planck Institute of Biochemistry

For specific information about this project and applications, please contact Boris Pfander (bpfander@biochem.mpg.de).

The institutions contributing to the CRC 1064 are equal opportunity employers.
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Über Max Planck Institute of Biochemistry

Proteins are the molecular building blocks and engines of the cell, and are involved in almost all processes of life. The scientists at the Max Planck Institute of Biochemistry (MPIB) investigate the structure of proteins and how they function – from individual molecules up to whole organisms. With about 850 employees coming from 45 nations, the MPIB is one of the largest institutes...

Mehr über die Max Planck Institute of Biochemistry

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