PhD position in Molecular Immunology LIMES Bonn

The laboratory of Dr. Eva Kiermaier is seeking for highly motivated PhD students (m/f, paycale TVL 13 65%) who aim to conduct their PhD thesis in a multidisciplinary field.
The lab focuses on different aspects of centrosome biology in immune cells and its relationship to cancer development.
Centrosomes are small organelles, which nucleate and organize the microtubule cytoskeleton in most animal cells. They are implicated in many physiological as well as pathological processes such as spindle formation during mitosis and tumorigenesis.
Similarly to most cancer cells, dendritic cells, the most potent antigen presenting cells of the innate immune system, harbor multinumerous centrosomes (Kiermaier et al., unpublished data). Interestingly, extra centrosomes have recently been shown to be sufficient to drive a somatic cell into a tumor cell (Ganem et al., Nature, 2009; Levine et al., Dev Cell, 2017).
We aim to understand the physiological role of extra centrosomes, how they are organized during immune cell effector functions and elucidate the mechanisms, which prevent dendritic cells from transforming into tumor cells despite their surplus of centrosomes.
To answer these questions we are employing a multidisciplinary approach and combine in vitro experiments with studies in living tissues. We use various cell biological assays and state-of-the-art techniques to genetically engineer cells (CRISPR/Cas9 system) and follow cell behavior by advanced 4D live cell imaging and super-resolution microscopy.
The position covers a 3 year working contract within a payscale of TVL13 65% and will be available by February 2018 and conducted at the Life and Medical Sciences (LIMES) Institute in Bonn.

The University of Bonn is an equal opportunity employer.
Kontakt für Bewerbungen
Dr. Evi Kiermeier
University of Bonn
Carl-Troll-Str. 31
53115 Bonn
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Über Universität Bonn

The Institute of Molecular Medicine and Experimental Immunology (IMMEI) was founded in 2002.It is situated on the medical Campus of the Friedrich-Wilhelms-Universitat Bonn. The scientific mission of IMMEI is to understand the molecular and cellular mechanisms controlling the immune response in a local fashion to develop either into immunity or immune tolerance. Comprehensive knowledge of the...

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