PhD Position in Interaction of the circadian clock and the reward system in metabolic regulation

The researchers in the DFG-funded Graduiertenkolleg 1957 study the effects of adipose tissue hormones on CNS function and in turn, the control of adipose tissue physiology by the brain. We are looking for highly motivated candidates for the PhD project (see title).
Tentative start: May 2020. Earlier start date could be discussed with the PIs in the interview.

Activities and responsibilities

Project Description:

Internal circadian clocks synchronize physiological functions to the time of day. In our modern society with unlimited nutrient access, excess intake of palatable food is common. The vulnerability to such hedonic overconsumption shows a 24-h rhythm and, thus snack timing may affect bodyweight regulation. We hypothesize that hedonic stimuli could serve as Zeitgeber for clocks in appetite regulating centers in the brain and, further, on clocks in metabolic tissues such as adipose. Studying the mechanisms of this communication is the focus of this project.

Experimental Methods:
  • Working with genetically modified mice (knock-out mice), including breeding strategies
  • Phenotyping of mice including measurement of sleep-wake behavior, food intake, thermogenesis, energy expenditure and body weight
  • Organotypic slice cultures with long-term luminescence recordings
  • Immunohistochemical analyses
  • DNA and RNA extraction
  • PCR, qPCR, in-situ hybridization

Qualification profile

  • Research-based master's degree or equivalent (e.g. diploma) passed with an excellent grade in biology, biochemistry, molecular life science, neuroscience, nutrition & biomedicine, pharmacology or a related subject
  • Excellent English language skills in speaking and writing
  • Pro-active attitude, good communication skills and ability to work independently in an interdisciplinary team

Send application to

GRK1957 Office, chaoqun.jiang(at)uni-luebeck.de

https://www.grk1957.uni-luebeck.de/grk-1957/phd-positions-on-adipocyte-brain-crosstalk.html

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Über University of Lübeck

Welcome at the GRK1957 "Adipocyte-Brain Crosstalk"Our DFG funded  Graduiertenkolleg 1957  offers focused research projects and a structured training programme. In an interdisciplinary research approach we address the effects of hormones derived from adipose tissue (adipokines) on CNS function and, in turn, the control of adipose tissue and body weight by the brain. ...
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