PhD Position in The role of the SCN clock in the regulation of leptin signaling in the brain

The researchers in the DFG-funded Graduiertenkolleg 1957 study the effects of adipose tissue hormones on CNS function and in turn, the control of adipose tissue physiology by the brain. We are looking for highly motivated candidates for the PhD project (see title).
Tentative start: May 2020. Earlier start date could be discussed with the PIs in the interview.

Activities and responsibilities

Project Description:

In mammals, a master circadian clock in the suprachiasmatic nucleus (SCN) synchronizes different central and peripheral tissue clocks to organize physiology and behavior across the 24-h day cycle. The adipokine hormone leptin is a major regulator of appetite and energy expenditure, acting via hypothalamic circuits. In obesity the brain becomes leptin resistant while at the same time circadian rhythms become disrupted. We hypothesize that circadian coordination of SCN-derived and feeding state-related signals determines the efficiency of leptin signaling to the brain, thus shielding the brain from a loss of leptin sensitivity and preserving its weight-controlling function under high-fat diet conditions.

Experimental Methods:
  • Working with genetically modified mice (knock-out mice), including breeding strategies
  • Phenotyping of mice including measurement of sleep-wake behavior, food intake, thermogenesis, energy expenditure and body weight
  • Organotypic slice cultures with long-term luminescence recordings
  • Immunohistochemical analyses
  • DNA and RNA extraction
  • PCR, qPCR, in-situ hybridization

Qualification profile

  • Research-based master's degree or equivalent (e.g. diploma) passed with an excellent grade in biology, biochemistry, molecular life science, neuroscience, nutrition & biomedicine, pharmacology or a related subject
  • Excellent English language skills in speaking and writing
  • Pro-active attitude, good communication skills and ability to work independently in an interdisciplinary team

Send application to

GRK1957 Office, chaoqun.jiang(at)uni-luebeck.de

https://www.grk1957.uni-luebeck.de/grk-1957/phd-positions-on-adipocyte-brain-crosstalk.html

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Über University of Lübeck

Welcome at the GRK1957 "Adipocyte-Brain Crosstalk"Our DFG funded  Graduiertenkolleg 1957  offers focused research projects and a structured training programme. In an interdisciplinary research approach we address the effects of hormones derived from adipose tissue (adipokines) on CNS function and, in turn, the control of adipose tissue and body weight by the brain. ...
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