PhD Position in TRH neurons in the energy homeostasis and regulation of brown adipose tissue

The researchers in the DFG-funded Graduiertenkolleg 1957 study the effects of adipose tissue hormones on CNS function and in turn, the control of adipose tissue physiology by the brain. We are looking for highly motivated candidates for the PhD project (see title).
Tentative start: May 2020. Earlier start date could be discussed with the PIs in the interview.

Activities and responsibilities

Project Description:

Regulation of the thermogenesis mediated by the uncoupling protein 1 (UCP1) is the specific metabolic function of brown (BAT). The central administration of thyroid releasing hormone (TRH) increases the body temperature and BAT activity. In the central nervous system the TRH neurons and the TRH-receptors are widely distributed. However, the neurological pathways in the regulation of body temperature and BAT activity is still unknown. In this project, we want to clarify these pathways using transgenic mouse models in combination with recombinant adeno associated viral vectors.

Experimental Methods:
  • Working with genetically modified mice (knock-out mice), including breeding strategies
  • Generation, production and icv application of rAAV vectors
  • Phenotyping of mice including measurement of thermogenesis, energy expenditure and body weight
  • Immunohistochemical analyses of TRH neurons and their projections
  • DNA, mRNA, protein extraction and quantification

Qualification profile

  • Research-based master's degree or equivalent (e.g. diploma) passed with an excellent grade in biology, biochemistry, molecular life science, neuroscience, nutrition & biomedicine, pharmacology or a related subject
  • Excellent English language skills in speaking and writing
  • Pro-active attitude, good communication skills and ability to work independently in an interdisciplinary team

Send application to

GRK1957 Office, chaoqun.jiang(at)uni-luebeck.de

https://www.grk1957.uni-luebeck.de/grk-1957/phd-positions-on-adipocyte-brain-crosstalk.html

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Über University of Lübeck

Welcome at the GRK1957 "Adipocyte-Brain Crosstalk"Our DFG funded  Graduiertenkolleg 1957  offers focused research projects and a structured training programme. In an interdisciplinary research approach we address the effects of hormones derived from adipose tissue (adipokines) on CNS function and, in turn, the control of adipose tissue and body weight by the brain. ...
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