PhD Student

The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them.

In the Department of Neurology (Head: Prof. Dr. Heinz Wiendl) we are looking for a

PhD Student
Ref. 11916

Salary according to TV-L E 13 (65 %)
Initially limited for one year until the end of the project 31.12.2017 with the possibility of extension for three years.
Starting date: 01.01.2017 or earlier.

We are interested in the role of the innate immune system in the pathogenesis of neurodegenerative diseases. Recent research breakthroughs have found strong associations between variants in several genes implicated in the immune response and the development of late onset Alzheimer’s disease. Functional assessment of such variants has been hampered by the lack of accurate tissue culture and animal models. We will establish a powerful human tissue culture model by generating microglia from human pluripotent stem cells, which may be used to unveil the molecular mechanism underlying established Alzheimer’s disease risk variants.

The successful applicant will be supervised by Dr. Matthias Pawlowski and work at the Max Plank Institute for Cell and Developmental Biology and at the Institute for Translational Neurology. Dr. Pawlowski has spent several years at the Cambridge Stem Cell Institute (Cambridge, UK) and has acquired extensive expertise in cellular reprogramming techniques. The excellent research environment at the MPI and the Department of Neurology ensures high quality research and optimal networking opportunities and thus a strong prospect of career development. The position is available from 01.01.2017 or earlier and initially restricted to one year with a prospect of extension for two additional years.

The successful applicant will receive training from a team with strong expertise in stem cell biology and immunology. Techniques will include human pluripotent stem cell culture, CRISPR/Cas9 gene editing, cellular reprogramming, molecular cloning, lentivirus production and a broad range of assays for the characterisation of human cells including qPCR, immunocytochemistry, calcium imaging, patch-clamping and genome-wide expression profiling.

The candidate should possess a Diploma (Master) in Biology, Biomedicine, Biochemistry or related fields. Previous experience with any of the above mentioned techniques is desirable. This position requires a highly motivated individual with a clear dedication to research. The applicant should be able to work independently with a high level of organization.

For further information please contact Dr. Matthias Pawlowski (

Applications of women are specifically invited. In the case of similar qualifications, competence, and specific achievements, women will be considered on preferential terms within the framework of the legal possibilities. Handicapped candidates with equivalent qualifications will be given preference.

How to apply:
Please send your application by giving the reference number 11916 until 31.10.2016.
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Die Medizinische Fakultät der Universität Münster zählt zu den größten und forschungsintensivsten in Deutschland. Klare Schwerpunkte, eine hohe Innovationskraft und die enge Bindung zum Universitätsklinikum Münster (UKM) – sie schaffen hier den Nährboden für neue Forschungserfolge. Damit diese Erfolge wachsen können, zählen wir...

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