PhD student positions immediately available

PhD student position immediately available

Background

The lab is interested in signal transduction pathways regulating different aspects of myogenesis and formation/maintenance of neuromuscular synapses.

Selected Previous Work

Huraskin et al, Development, 2016:
Here, we elucidated the role of canonical Wnt signaling activity in adult muscle fibers using a well-established Axin2-lacZ reporter mouse paradigm. In these mice, canonical Wnt signaling is reflected by lacZ expression under control of the endogenous Axin2 promoter. We detected active canonical Wnt signaling (1) in myotubes derived from cultured C2C12 cells or murine primary myoblasts, (2) in muscle fibers of type IIa and, most likely, type IIx, (3) at neuromuscular synapses and (4) during regeneration of skeletal muscle after injury. Interestingly, YAP/Taz/Tead1-mediated signaling accompanied canonical Wnt signaling in adult muscle fibers.

Cheusova et al., Autophagy, accepted:
Here, we asked whether CSNK2 phosphorylates TOMM22 in skeletal muscle fibers of mice and whether this influences mitochondrial physiology. We show that (1) CSNK2 phosphorylates TOMM22, (2) CSNK2-dependent TOMM22 phosphorylation is not involved in the regulation of mitochondrial protein import in vitro, (3) skeletal muscles from skeletal muscle Csnk2b cKO mice contain dysfunctional mitochondria, and (4) mitophagy markers are involved in the removal of impaired mitochondria.

Project

The projects in the lab deal with better understanding of molecular pathways in myogenesis in health and disease. To this end, we use genetically modified mice with floxed alleles. We analyze muscle phenotypes of mutant mice by their behavior, grip strength measurements, and histological / histochemical / immunostainings of muscle sections. We investigate the NMJs of the mutant mice by structural and functional approaches, like 3D morphometrical imaging, and electrophysiological recordings of neuromuscular transmission. Muscular target genes will be analyzed by RNA-Seq. Altogether, our projects help to understand individual and concerted roles of both signaling pathways regarding neuromuscular biology.

Your profile

Our lab is speaking english and german language (you should be able to speak one of both). PhD student candidates should have a degree in a relevant field and be highly motivated scientists. They will obtain a monthly salary of ~1.450,-- € after tax. Please send your curriculum vitae and contact information of references asap by e-mail.
 
How to apply:
Please send your application as a single PDF by E-Mail.
Kontakt für Bewerbungen
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Prof. Dr. Said Hashemolhosseini
Institut für Biochemie, Medizinische Fakultät
Universität Erlangen-Nürnberg
Fahrstr. 17
91054 Erlangen
Germany

Phone  +49-9131-85-24634

said.hashemolhosseini@fau.de
http://www.biochem.uni-erlangen.de
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Über Universität Erlangen-Nürnberg

Das Institut für Biochemie ist an der vorklinischen Ausbildung von Medizinern beteiligt. Daneben verfolgen die verschiedenen Forschergruppen Ihre eigenen ud Drittmittel-finanzierten Forschungsprojekte.

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