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Postdoc Position - cell biology, genetics, biochemistry - Protein Homeostasis in Ageing and Disease


CECAD-Cluster of Excellence in Ageing Research

- Protein Homeostasis in Ageing and Disease -
Location: Cologne is a vibrant city with a highly international academic research environment. CECAD forms a focal point of ageing research in Europe bringing together researchers and clinicians at the University of Cologne with researchers at the new Max Planck Institute for Biology of Ageing in a unique research venture.
Website: http://www.hoppelab.uni-koeln.de
Summary: Organismal development or environmental stimuli challenge the homeostatic protein balance of individual cells or the entire organism. Protein homeostasis is typically maintained by a concerted interplay between protein translation, protein folding or turnover of unfolded or damaged proteins.  The ubiquitin proteasome system (UPS) regulates selective degradation of cellular proteins supporting cellular protein homeostasis and thereby maintains the proteome during stress and ageing. Degradation of damaged proteins is mediated by the 26S proteasome upon attachment of ubiquitin. An age-related impairment of the UPS causes enhanced protein aggregation and affects lifespan. The ultimate goal of the proposed research is to answer the fascinating question as to how inter-cellular communication regulates the UPS during multicellular development, stress and ageing.
Job description: We are seeking a highly motivated Postdoc to join our enthusiastic and collaborative group where a multidisciplinary approach is pursued. We are using both genetic and biochemical approaches primarily in the C. elegans but also in mammalian systems to investigate proteolytic networks in ageing and disease.
Qualification: Successful applicants should have a solid background in molecular biology and experience in cell biology, genetics or biochemistry. Candidates should have demonstrated outstanding performance through their undergraduate studies and by high impact publications. Besides creativity, a strong ability for problem solving through analytical thinking combined with an enthusiasm for scientific research is highly desirable. Additionally, we expect good communication skills, fluent English and the ability for teamwork.

Selected Publications:
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Franz A, Pirson PA, Pilger D, Halder S, Achuthankutty D, Ramadan K, Hoppe T (2016). Nat Commun, 7: 10612.
Pathogenesis of Human Mitochondrial Diseases Is Modulated by Reduced Activity of the Ubiquitin/Proteasome-System. Segref A, Kevei E, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R,  Glickman MH, Ristow M, Hoppe T (2014). Cell Metab., 19, 642-52.
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Ermolaeva M, Segref A, Dakhovnik A, Ou H-L, Schneider J, Utermöhlen O, Hoppe T, Schumacher B. (2013). Nature, 501, 416-20.
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T*, and Clausen, T (2013). Cell, 152, 183-95. (*co-corresponding author)
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Kuhlbrodt K, Janiesch PC, Kevei E, Segref A, Barikbin R, and Hoppe T (2011). Nat. Cell Biol. 13, 273-81.
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Franz A, Orth M, Pirson PA, Sonneville R, Blow JJ, Gartner A, Stemmann O, Hoppe T* (2011). Mol Cell. 44, 85-96. (*co-corresponding author)
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Janiesch  PC, Kim J, Mouysset J, Barikbin R, Lochmüller H, Cassata G, Krause S, and Hoppe T* (2007). Nat Cell Biol. 4, 379-90. (*co-corresponding author)
Ackermann L, Schell M, Pokrzywa W, Kevei E, Gartner B, Schumacher B, Hoppe T. E4 Ubiquitin Ligase Specific Degradation Hubs Coordinate DNA Double Strands Break Repair (2016). Nat Struct Mol Biol. (in press)

How to apply:
How to Apply:

Please send your CV, letter of intent, names and addresses of three references to office-hoppe@uni-koeln.de
Kontakt für Bewerbungen

Institution information:

Prof. Thorsten Hoppe
University of Cologne
Institute for Genetics
CECAD Research Center
Joseph-Stelzmann-Str. 26
50931 Cologne, Germany
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Über Universität zu Köln

Institut für Genetik, Arbeitsgruppe Prof. Dr. Thorsten Hoppe CECAD Cluster of Excellence in Ageing Research Protein Homeostasis in Ageing and Disease

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