PhD student position in Immunology at the University of Lübeck, Germany

Our Laboratory of Immunology at the University of Lübeck works on the development and function of antibodies. IgG antibodies are not only effector molecules of pathogenic and pro-inflammatory immune responses but can also be mediators of tolerogenic immune responses such as regulatory T cells. The inhibitory function is mediated through a specific kind of IgG Fc glycosylation. Our laboratory has discovered that antigen-specific sialylated IgG antibodies can be used to inhibit pro-inflammatory immune responses in an antigen-specific manner (Oefner et al, JACI 2012, 129(6):1647-1655; Karsten et al, Nature Medicine 2012, 18(9):1401-1406; Hess et al, JCI 2013, 123(9):3788–3796; Strait et al, Nature 2015, 517(7535):501-504; Epp et al, JACI 2018, 141 (1):399-402.e8; Bartsch et al, Front Immunol 2018, 9:1183). Accordingly, we also produce our own monoclonal antibodies with different glyco-forms to investigate their potential in different autoimmune, allergy, vaccination and transplantation models.

For upcoming research projects to investigate how differentially glycosylated pro-inflammatory or immunosuppressive IgG antibodies develop and function in human and mice in the context of autoimmunity, allergy or vaccination against pathogens and tumors, we are looking for a highly motivated PhD student candidate.
Please contact Prof. Marc Ehlers (email: marc.ehlers@uksh.de ) for further informations and application (via email).
 
How to apply:
via email: marc.ehlers@uk-sh.de
 

Activities and responsibilities

You would also work with mice.

Qualification profile

We are looking for a highly motivated PhD student candidate. Experience with mice and flow cytometry would be good.

Send application to

Prof. Marc Ehlers
Institute for Nutrition Medicine
University of Lübeck
Ratzeburger Allee
23562 Lübeck
Germany
email: marc.ehlers@uksh.de

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