PhD - Protein folding in vivo and in vitro (m/f)

 University of Michigan  Ann Arbor, MI, USA
We are seeking highly motivated individuals with a M.Sc. or Diploma degree who would like to conduct the research for their PhD thesis in our lab (about 3 years, $28,500/year). The student can pick the starting date.

Our lab studies protein folding both in the test tube and in the cell. We aim to understand protein folding well enough to be able to manipulate it. We ask organisms themselves to solve protein folding problems. By examining their solutions we can better understand folding in the cell. We have developed folding biosensors that link protein stability to antibiotic resistance. They enable us to optimize folding in vivo (1) and discover new molecular chaperones (2). Protein folding in the cell is intimately tied to the action of folding catalysts and chaperones. We study the action of these folding helpers both in vivo and in vitro using a wide range of genetic, biochemical, biophysical and structural techniques (2,3).

We have a lot of experience working with German graduate, master and diploma students and can help with the paperwork. Our lab is located at the University of Michigan, one of top five public schools in the country, which provides an excellent research environment.

1. Foit L et al (2009) Optimizing protein stability in vivo. Mol Cell 36: 861-871.
2. Quan (2011) Genetic selection designed to stabilize proteins uncovers a 
chaperone called Spy. Nature Struct. Mol. Biol.18(3):262-9
3. Foit L et al. (2011) Chaperone activation by unfolding. PNAS 110(14):E1254-62.

How to apply:
Please email CV, current transcript/list of classes taken and contact information for at least two references to James Bardwell (
Kontakt für Bewerbungen
Dr. James C. A. Bardwell
University of Michigan
Department of Molecular, Cellular, and Developmental Biology
Natural Science Building, Room 4007A
830 N. University
Ann Arbor, MI 48109
Phone: +1-734-764-8028
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Über University of Michigan

The MCDB department at the University of Michigan consits of thirty-two faculty and over sixty Ph.D. students whose charge is to increase knowledge of living organisms. To do this we focus on basic research at the molecular and cellular levels of all branches of life - bacteria, plants, and animals. Recent advances in the molecular biosciences have led to an explosion of knowledge, providing a...

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