PhD position - Master's degree (or equivalent) in biology, physics, chemistry, biochemistry, engineering, medicine, bioinformatics, biotechnology, modeling, image analysis - Research in mechanobiology

The graduate school Mechanobiology in Epithelial 3D Tissue Constructs (MEƎT) trains doctoral researchers in the burgeoning fields of mechanobiology and tissue engineering. The doctoral researchers examine how mechanical stimuli regulate tissue morphogenesis and remodeling based on the hypothesis that the micromechanical niche determines cellular responses which in turn modify the cell's mechanical niche. Understanding and controlling this mechanobiological feedback cycle offers novel prospects for steering tissue morphogenesis and remodeling in order to interrupt pathological processes and produce functional tissue Substitutes Cell biology, biophysics and bioengineering must work hand in hand to unravel fundamental mechanobiological mechanisms. MEƎT exploits the unique constellation at RWTH Aachen University by bringing together engineers and life science researchers to provide an ideal basis for meeting this demand. The doctoral researchers leverage this constellation to learn about mechanisms governing tissue mechanics and development, and use this knowledge for developing tissue engineered biological systems.

Activities and responsibilities

MEƎT's doctoral researchers have a large toolbox at their disposal and supplement it to provide 3D biomaterial-based culture systems with spatially and temporally controlled mechanical properties. The research activities are embedded in a curriculum that is tailored to the interdisciplinary needs of research in mechanobiology.

Qualification profile

Successful applicants should have an excellent Master's degree (or equivalent) in biology, physics, chemistry, biochemistry, engineering, medicine,  bioinformatics, biotechnology, modeling,image analysis or any other relevant field. Fluency in English is required.

Benefits

MEƎT brings together a multidisciplinary team including experts in biophysics, stem cell and molecular biology, material science, bioengineering and medicine. The common scientific focus is on the mechanobiology of surface-lining epithelia such as the skin which is exposed to extreme mechanical strain. It is our goal to use the gained knowledge for improved tissue engineering and treating human diseases.
A structured curriculum is offered in English to prepare doctoral researchers for a career in an international environment either in the public or private sector.

Send application to

Prof. Dr. Rudolf E. Leube
Institute of Molecular and Cellular Anatomy
RWTH Aachen University
Wendlingweg 2
D-52074 Aachen

Phone: +49 (0) 241 80 89107
Email: rleube@ukaachen.de
Web: me3t.rwth-aachen.de

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Das Institut für Molekulare und Zelluläre Anatomie gehört zum Universitätsklinikum der RWTH Aachen. Es beteiligt sich an allen Lehrveranstaltungen der mikroskopischen und makroskopischen Anatomie. Darüber hinaus werden Seminare und Kurse zu zell- und entwicklungsbiologischen Fragestellungen angeboten. Die Forschung konzentriert sich auf die Analyse des Zytoskeletts und...

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