PhD position Molecular Biology, Immunology, Biochemistry

We offer a PhD position at the University Clinic Freiburg, Dept. Neuropathology, AG Molecular genetics (Knobeloch Lab)
Our work is focused on proteases counteracting protein modification by ubiquitin and ubiquitin-like modifiers such as ISG15 and SUMO. We generate conditional knockout mice for different Ubiquitin specific proteases (USPs) and use a wide range of molecular, immunological and cellular technologies to define physiological and molecular functions. A selection of recent publications is listed below (1-4).

For this particular DFG funded project (3 years) we generated a novel conditional knockout mouse line for a sparsely investigated SUMO-specific protease. As this isopeptidase was reported to additionally harbour non-enzymatic functions, a second mouse line with selective inactivation of only the catalytic activity was engineered. The task of this project is to define and dissect enzymatic and non-enzymatic molecular and physiological functions of this particular USP within the context of the whole organism.

The applicant should hold a master degree or equivalent in Biology, Molecular Medicine, Immunology, Biochemistry or a related field. A strong interest in molecular biology and willingness to work with mice is mandatory. Experience with ubiquitin or SUMO modification and/or mouse genetics is a plus. Beside creativity and strong motivation we expect good communication skills and the ability for teamwork.

We offer a straightforward project which is based on extensive unpublished preliminary data and provide excellent working conditions in a highly motivated environment where hard work does not exclude fun.
Commencement of employment is sceduled for august, but flexible within a reasonable timeframe.

Please apply online providing a letter of interest, marks, credits, theme of the master/bachelor thesis, CV, and if available publications.

1. Basters, A. et al. Structural basis of the specificity of USP18 toward ISG15. Nature structural & molecular biology, doi:10.1038/nsmb.3371 (2017).
2. Ketscher, L. et al. Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance. Proc Natl Acad Sci U S A 112, 1577-1582, doi:10.1073/pnas.1412881112 (2015).
3. Goldmann, T. et al. USP18 lack in microglia causes destructive interferonopathy of the mouse brain. The EMBO journal 34, 1612-1629, doi:10.15252/embj.201490791 (2015).
4.  Dufner, A. et al. The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Nature immunology 16, 950-960, doi:10.1038/ni.3230 (2015).
Kontakt für Bewerbungen
PD Dr. rer. nat. Klaus-Peter Knobeloch
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Über Uniklinik Freiburg

Basic research in the institute of Neuropathology which is headed by Marco Prinz is focused on Neuroimmunology, innate immunity and inflammation. Knockout mouse models are used to elucidate molecular and cellular mechanisms underlying major diseases like multiple sclerosis or Alzheimer disease. A strong interest  on the molecular level lies  in the analysis of in vivo functions of...

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