PhD-student (m/f/d) in cell biology - "Mitochondrial architecture and dynamics"

The research at the University Medical Center Göttingen and at the Max Planck Institute (MPI) for Biophysical Chemistry in Göttingen encompasses a wide spectrum of scientific topics and techniques. Of central concern are the mechanisms by which cells, organelles and biomolecules fulfill their manifold tasks. Ultra-high-resolution microscopy, nanotechnology, nuclear magnetic resonance spectroscopy, mass spectrometry and computer simulation are employed to delve ever-further into the nanocosmos of living cells.

Activities and responsibilities

We want to understand the biogenesis and development of the mitochondrial inner architecture, especially of the crista membranes. A large number of proteins are involved in the formation and maintenance of the folding of the mitochondrial inner membrane: We want to understand the interaction of these factors on the nanoscale. You will analyze the composition, dynamics and function of these proteins using a wide range of methods from molecular biology (e.g. CRISPR/Cas9 genome-editing), biochemistry, high-resolution microscopy (STED, MINFLUX, RESOLFT nanoscopy and others) and quantitative immuno-gold electron microscopy on model systems like cultured human cells and yeast cells. Your project will be embedded in a larger research project funded by the European Union (ERCAdG MitoCRISTAE).

Qualification profile

You are a highly motivated and curiosity driven biologist/biochemist/biophysicist who wants to work in a multidisciplinary team of biologists, physicists and chemists on the cell biology of mitochondria. You hold an excellent university degree in biology, biochemistry, biophysics or a related discipline. Knowledge of (super‑resolution) light microscopy and/or molecular biology and cell biology is of advantage. Independent thinking, structured work organization and a good team spirit are expected.

We offer

The research group Mitochondrial Structure and Dynamics is investigating the mechanisms by which the inner-mitochondrial architecture is determined and maintained. We are using a wide variety of experimental approaches that include molecular and biochemical tools, in particular electron and advanced super-resolution light microscopy, as well as live-cell imaging microscopy. Our group offers an outstanding and unique scientific setting with lot of individual freedom and possibilities for individual development as well as a vibrant working environment.
The salary is in accordance with the German Public Service salary scale (TV-L E13) with 65% of the regular working hours.

Send application to

Do not hesitate to contact us if you have any further questions regarding the project and position.

We would like to actively increase the proportion of female scientists at the University Medical Center Göttingen and in the Max Planck Society and therefore particularly welcome applications from female students. We are also committed to employing more disabled persons and especially encourage them to apply.

Important note: the applicant must be able to come to Göttingen for a personal interview.
Please send inquiries and your application (preferably as a single PDF) to

Prof. Stefan Jakobs
University Medical Center Göttingen
Clinc for Neurology
c/o
MPI for biophysical Chemistry
AG Mitochondrial Structure and Dynamics
Am Fassberg 11
37077 Göttingen

Email: jakobs-lab@gwdg.de
Twitter: @JakobsLab
www.mitoweb.de

Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: MitoCRISTAE

Über Max-Planck-Institut für biophysikalische Chemie, Abtl. NanoBiophotonics

Die Forschung am Max-Planck-Institut (MPI) für biophysikalische Chemie in Göttingen umfasst ein breites Spektrum an wissenschaftlichen Fragestellungen und Techniken. Der zentrale Punkt der Forschung liegt im Verständnis der Mechanismen mit denen Zellen, Organellen und Biomoleküle ihre vielfältigen Aufgaben bewältigen. Ultra-hochauflösende Mikroskopie, Nanotechnologie,...
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