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Research post-doctoral fellowship in cancer cell signaling

The Department of Hematology/Oncology, Medical Center, has on opening for one Post-Doc (Ph.D., graduate-) position (E13 TV-L) for two years. Thereafter, further extension of the contract or a permanent position will be considered.
We are looking for enthusiastic and highly motivated applicants holding, or about to obtain, a PhD degree. The applicants should possess a strong research background in molecular and cell biology, previous experience in cancer research will be an advantage. Preference will be given to applicants with previous experience in one or more of the following areas: Analysis of cell signaling (protein biochemistry or flow-cytometry based) and in vivo analysis of hematopoiesis or leukemia (using mouse models in hematology, oncology or immunology, as animal work will be mandatory).
The applicant needs to hold at least one of the following degrees: diploma or masters in biological sciences or medical degree.
The research project investigates molecular mechanisms of oncogenic signaling in human leukemia and myeloproliferative neoplasia including functional analysis of relevant signaling molecules in mouse models. This theme will be expected to connect with major “on campus” subjects as signal transduction, inflammation and immunology.
The candidate will be integrated in a friendly team of highly motivated scientists and physicians and will be working in an internationally visible and fully equipped laboratory. Several national and international collaborations are ongoing.
Several research projects of our laboratory are participating in multicenter research programs funded by the Else-Kröner-Fresenius-Stiftung (EKFS), the BMBF and projects within the local Collaborative Research Cluster (Sonderforschungsbereich; SFB854).
For further information please visit: http://www.med.uni-magdeburg.de/KHAE.html, http://www.sfb854.de/index.html, and http://www.med.uni-magdeburg.de/fme/grk/.
Markova B, Albers C, Breitenbuecher F, Melo JV, Brümmendorf TH, Heidel F, Lipka D, Duyster J, Huber C and Fischer T. Novel pathway in Bcr-Abl signal transduction involves Akt-independent, PLC-gamma1-driven activation of mTOR/p70S6-kinase pathway. Oncogene. 2010 Feb 4;29(5):739-51. Epub 2009 Nov 2.
Heidel FH, Bullinger L, Feng Z, Wang Z, Neff TA, Stein L, Kalaitzidis D, Lane SW and Armstrong SA. Genetic and Pharmacologic Inhibition of b-Catenin Targets Imatinib Resistant Leukemia Stem Cells in CML. Cell Stem Cell 2012. Apr 6;10(4):412-24.
Heidel FH, Bullinger L, Arreba-Tutusaus P, Wang Z, Gaebel J, Hirt C, Niederwieser D, Lane SW, Dohner K Vasioukhin V, Fischer T and Armstrong SA. The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML. J Exp Med 2013 Jan 14;210(1):15-22. doi: 10.1084/jem.20120596.
Wagner MC, Dziadosz M, Melo JV, Heidel F, Fischer T and Lipka DB. Nilotinib shows prolonged intracellular accumulation upon pulse-exposure: a novel mechanism for induction of apoptosis in CML cells. Leukemia. doi:10.1038/leu.2012.364; December 12, 2012

How to apply:
Please submit your application, including CV and references to thomas.fischer@med.ovgu.de or to:

Prof. Dr. Th. Fischer
Direktor der Klinik für Hämatologie und Onkologie
Universitätsklinikum Magdeburg
Leipziger Straße 44
D-39120 Magdeburg
Kontakt für Bewerbungen
For additional information, please contact
Prof. Dr. med. T. Fischer, Director, Department of Hematology and Oncology, (thomas.fischer@med.ovgu.de); Phone: +49 391 67 13266; Fax: +49 391 67 13267
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Über Universitätsklinikum der Otto-von-Guericke Universität Magdeburg

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