Master Thesis "Development of cell-free enzyme cascade for in-vitro glycosylation"

Glycosylation is an important modification of proteins, and is involved in the regulation of biological activity and stability of many proteins. Furthermore, glycosylated proteins play an important role in the development of therapeutics. At the MPI Magdeburg, in-vitro enzyme cascades are build up to synthesize defined glycoproteins.

Activities and responsibilities

The focus of the project will be as follows:
  • Recombinant production of enzymes from the glycosylation machinery in microbial systems
  • Downstream Processing of enzymes and membrane proteins
  • Protein analytics and enzyme reactions with different reaction conditions

The candidates will have the opportunity to work on key technologies and use state-of-the-art equipment in an international group of researchers. In-depth supervision and training will be provided by MPI staff.

Qualification profile

  • Background in Biotechnology, Technical Biology, Bioprocess Engineering, Bioengineering
  • Good experience of lab works and ideally, experience with one of the following techniques: protein expression, protein analytic, protein purification and molecular biology methods
  • Motivation, curiosity and team work skills

We offer

  • Exciting research projects and the opportunity to develop key technologies
  • Firstclass supervision and thorough training by our staff
  • Training on stateof-the-art equipment for biotechnological research and development
  • Acquisition of expertise in a key technology of the future
Start:
October/November 2019

Send application to

Please send your application in German or English and include your CV and transcript of records to the following contacts:

Dr. Thomas Rexer
E-Mail: rexer@mpi-magdeburg.mpg.de
Phone: +49 (0) 391 6110 375

Lisa Wenzel, M.Sc.
E-Mail: wenzell@mpi-magdeburg.mpg.de
Phone: +49 (0) 391 6110 229

The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds. Furthermore, the Max-Planck society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.

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Über Max Planck Institute for Dynamics of Complex Dynamical Systems

In 1996 the Max Planck Institute for Dynamics of Complex Technical Systems was established. The founding director is Prof. em. Dr.-Ing. Ernst Dieter Gilles. The institute in Magdeburg is the first institute of the Max Planck Society dedicated to the engineering sciences and is intended to bridge the gap between basic research and industrial applications. At present 240 employees are...
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