Doctoral researcher (f/m/d) Development of cells for counteracting local infections - redirecting infection signals to therapeutic effectors

The research group “Model Systems for Infection” of Prof. Dagmar Wirth at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany is seeking a
 
Doctoral researcher (f/m/d)

Project title:   Development of cells for counteracting local infections - redirecting infection signals to therapeutic effectors

Activities and responsibilities

Host cells use signaling networks to sense, transmit and counteract local infection events. This project aims to re-engineer these cellular signaling systems to establish sophisticated strategies of therapeutic effector expression. Therefore, cells (various cell lines, primary cells) will be equipped with synthetic expression cassettes that redirect physiological signals to enzymatic activities that block infection. To this end, advanced tools of genetic engineering including RMCE and CRISPR/Cas9 will be used. Validation of cells is foreseen in in vitro infection models. For proof of concept, the potential of these cells to cure infection will be evaluated in mouse models.

Qualification profile

  • Master’s Degree/Diploma in biology, biotechnology, or a related field of the life sciences
  • Excellent education/training in molecular biology/genetic engineering and high motivation to work in Synthetic Biology
  • Excellent English communication skills (written and spoken)
  • Ability to work both independently and within an international team

Benefits

Equal Opportunities are part of our personnel policy. Qualified applicants with a disability will be given preference.

Starting date:               June 2019 or later - Initial contract for 3 years

Salary:                          follows TVöD E13 (50%) with the possibility of an additional payment of 15%

Probation period:        6 months

Closing date:               31 March 2019

Application:                 Applicants are required to complete the online application form here:
                                      https://hzi.opencampus.net/ (Please select Job No. 23/2019).

Further information about the institute and the research group of Prof. Dagmar Wirth can be found on our website:
http://www.helmholtz-hzi.de/en/research/research_topics/immune_response/systems_for_infection_and_immunity/our_research/

Send application to

Applicants are required to complete the online application form here: https://hzi.opencampus.net/ (Please select Job No. 23/2019).

For questions regarding the PhD project, please contact Prof. Dagmar Wirth via e-mail Dagmar.Wirth@helmholtz-hzi.de or phone +49-531-6181-5040.

Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: 23/2019

Über Helmholtz-Zentrum für Infektionsforschung GmbH

Helmholtz-Zentrum für Infektionsforschung. Wir konzentrieren uns auf Bakterien, die medizinisch relevant sind oder als Modell für die Erforschung von Infektionsmechanismen genutzt werden. Mit unserer Arbeit leisten wir einen nachhaltigen Beitrag für die Gesundheitsvorsorge.

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