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1 PhD position "Stoichiometry of heteromeric assemblies across TRP channel families"

 Universität Freiburg  Freiburg
The Research Training Group 2202 „Transport across and into membranes“ at the University of Freiburg (Germany) welcomes applications for

1 PhD position working on "Stoichiometry of heteromeric assemblies across TRP channel families"
Part-time position (65%), starting date: 01.07.2016
The Research Training Group is funded by the DFG and focuses on the characterization of transport processes at a molecular level. The doctoral researchers examine the transport of ions, metabolites and proteins across and in the cell membrane using a huge variety of biochemical and biophysical techniques.
The three‐year structured program consists of lecture series, seminars, method courses, a summer school, and symposia. In addition, participants will be offered the possibility to attend courses for individual needs. Successful candidates will be awarded the PhD degree (Dr. rer. nat.). The program is taught in English.
The PhD position is open in the BIOSS Centre for Biological Signalling Studies in the Ulbrich laboratory (http://www.ulbrich-lab.com) and aims at elucidating the composition and assembly rules of heteromeric TRP channels. TRP channels are a family of ion channels that mediate different sensations like touch and temperature, respond to various ligands, and are classified into the six groups TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML. TRP channels seem quite promiscuous in the choice of their assembly partners. The formation of heteromeric channels implies a mixing of the properties of the different subunits into one protein, i.e. the activation modalities (e.g. ligand binding, temperature range) and conduction properties of the involved subunits will be combined, an effect of high biological relevance. Several heteromeric assembly possibilities of TRPs from the same or different groups have been suggested; however, the stoichiometry and a potential preference for certain subunit combinations remains unknown and a unifying pattern or deeper understanding of the underlying mechanism is missing. To decipher the stoichiometry of heteromeric TRP channels and identify molecular determinants that guide the assembly, we use a live cell single molecule imaging technique for subunit counting that is based on the identification of photobleaching steps from fluorescent labels fused to the channel subunits of interest. This approach allows determining the stoichiometry of membrane protein assemblies and the detection of a potential preference for certain stoichiometries over others.
▪ Diploma, Master or Bachelor s degree with honours (B.Sc. Hon. for a fast-track application) in Biochemistry, Biology, Biophysics, Chemistry, Physics, Molecular Medicine, Pharmacy or related fields
▪ High motivation and commitment
▪ Interest in active participation in the RTG program
▪ very good written and spoken English skills
Application documents:
▪ Application form (fillable PDF form: www.taim.uni-freiburg.de/application)
▪ Letter of motivation
▪ CV
▪ Transcripts of studies
▪ Two letters of recommendation
▪ Proof of fluency in English
The maximum duration of the PhD position will be three years. The salary is in accordance with the German public service salary scale (TV‐L E 13, 65%). The job advertisement is subject to the definitive financing commitment of the DFG. Further information: www.taim.uni-freiburg.de

How to apply:
Applications should be sent as one pdf file to rtg2202@bio.chemie.uni-freiburg.de. Please refer to Application RTG 2202 in the subject line. Further information http://www.taim.uni-freiburg
Kontakt für Bewerbungen
Coordinator RTG2202: rtg2202@bio.chemie.uni-freiburg.de
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