PhD Position in Impact of the ACE2/Ang(1-7)/Mas axis and the angiotensin A/alamandine/ MrgD axis on weight regulation

The researchers in the DFG-funded Graduiertenkolleg 1957 study the effects of adipose tissue hormones on CNS function and in turn, the control of adipose tissue physiology by the brain. We are looking for highly motivated candidates for the PhD project (see title).
Tentative start: May 2020. Earlier start date could be discussed with the PIs in the interview.

Activities and responsibilities

Project Description:
The classic ACE/AngII/AT1 receptor axis of the Renin Angiotensin System (RAS) regulates cardio­vascular and metabolic functions. Blockade of AT1 receptors prevents development of obesity by normalizing energy homeo­stasis via leptin, brain, and gut related mechanisms. An alternative RAS pathway (ACE2/Ang(1-7)/Mas) is estab­lished to also be involved although it remains unknown whether due to an adipocyte or brain related mecha­nism. We aim to investigate tissue specificity by using transgenic mouse models with an adipocyte and brain selective overexpression or deficiency of Mas or Ang(1-7). We further want to clarify whether the Ang(1-7)-dependent weight loss after ARB treatment is not only related to Mas but also to MrgD receptors.


Experimental Methods:
  • Working with genetically modified mice including breeding strategies
  • Chronic treatment of animals with drugs
  • Phenotyping of mice including measurement of blood pressure, heart rate, glucose control, energy expenditure, body weight and fat mass
  • Multiplex, ELISA, RIA analyses of adipokines and endocrine parameters
  • DNA and RNA extraction
  • PCR, qPCR (e.g. for analyzing components of the RAS in different tissue)

Qualification profile

  • Research-based master's degree or equivalent (e.g. diploma) passed with an excellent grade in biology, biochemistry, molecular life science, neuroscience, nutrition & biomedicine, pharmacology or a related subject
  • Excellent English language skills in speaking and writing
  • Pro-active attitude, good communication skills and ability to work independently in an interdisciplinary team

Send application to

GRK1957 Office, chaoqun.jiang(at)uni-luebeck.de

https://www.grk1957.uni-luebeck.de/grk-1957/phd-positions-on-adipocyte-brain-crosstalk.html

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Über University of Lübeck

Welcome at the GRK1957 "Adipocyte-Brain Crosstalk"Our DFG funded  Graduiertenkolleg 1957  offers focused research projects and a structured training programme. In an interdisciplinary research approach we address the effects of hormones derived from adipose tissue (adipokines) on CNS function and, in turn, the control of adipose tissue and body weight by the brain. ...
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