PhD Student / Scientific Assistant (m/f/d) in biophysics and super-resolution microscopy

At the Department of Physics within the Faculty of Mathematics and Natural Sciences of Heinrich Heine University Düsseldorf the position of a

PhD Student / Scientific Assistant (m/f/d)
(50%, pay grade 13 TV-L)

is to be occupied at the earliest possible date. The employment is initially limited for a period of three years with an option for prolongation for another year. It is a qualification position in the sense of the Act of Academic Fixed-Term Contract (Wissenschaftszeitvertragsgesetz – WissZeitVG), which is to promote the scientific qualification of the employee (m/f/d).
In the newly established group “Experimental Medical Physics” we employ (super-resolution) microscopy and bioimage data analysis approaches to study medically relevant cell processes down to the single-molecule level. In particular, we investigate how molecular structure and dynamics in healthy and malignant cells give rise to specific cell signals. In order to explore as well as actively alter these processes, our group develops nanotechnological tools such as magnetogenetics, where nanoparticles in conjunction with an external stimulus enable direct molecular manipulation.

Activities and responsibilities

Currently, we are looking for a PhD student (m/f/d) to explore the protein CD95, a prominent protein triggering cell apoptosis, which forms characteristic signaling complexes on the cell plasma membrane. The project will focus on monitoring and manipulating CD95 and its complex formation. To this end, we interrogate CD95 behaviour after passive or active stimulation in live cells using state-of-the-art microscopy and active magnetic manipulation. The project includes comprehensive live cell microscopy and analysis of the spatio-temporal dynamics of the receptor accumulation and interaction.
The candidate (m/f/d) will use biophysical and nanotechnological techniques, with focus on single particle tracking, FRET or STED and will analyze the image data with self-written routines in Matlab. These studies will be conducted in close collaboration with project partners within the CRC1208 and the Centre of Advanced Imaging.

Qualification profile

  • above-average master‘s degree in physics, biophysics, physical chemistry, nanotechnology
  • readiness to write a dissertation and/or scientific publication
  • strong interest in interdisciplinary research
  • skills in super resolution microscopy (single molecule tracking, STED, FRET) or image data analysis using Matlab is desirable
  • experience in handling of cells or molecular samples is welcome.
  • independent working and capacity to work in a team and with project partners
  • good command of written and spoken German and English

We offer

  • employment limited to 36 months
  • pay grade 13 TV-L (50% position)
  • Heinrich-Heine-University Düsseldorf aims at increasing the percentage of employed women. Applications from women will therefore be given preference in cases of equal aptitude, ability and professional achievements
  • applications from suitably qualified severely disabled persons or disabled persons regarded as being
    of equal status according to Book IX of the German Social Code (SGB – Soziales Gesetzbuch) are encouraged.

Send application to

Please submit your application documents (letter of motivation, CV, copies of education certificates, description of previous research experience) citing reference number 104.20 – 3.1 by e-mail to cornelia.monzel@hhu.de

For further information forward your enquiry directly to:
Prof. Dr. Cornelia Monzel
Phone: +49 (0)211 81 - 12893
Email: cornelia.monzel@hhu.de
Web: http://www.medicalphysics.hhu.de

Bitte beziehen Sie sich bei Ihrer Bewerbung auf jobvector und geben Sie die folgende Referenznummer an: 104.20-3.1

Über Heinrich-Heine Universität Düsseldorf

The "Experimental Medical Physics" group at HHU   Our group aims to understand the interplay of physical and biological mechanisms which give rise to cellular functions of relevance for medical diagnostics and therapy. To this end, we investigate the physical properties – the structure, mechanics and molecular dynamics - in healthy and malignant cells as well as explore fundamental...
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