Life and Brain Center Experimental Epileptology and Cognition Research

The Laboratory for Experimental Epileptology ‘The Laboratory for Experimental Epileptology is focused on understanding elementary integrative properties of neurons, and their disease-associated plasticity’
We are pursuing the following main goals related to information processing in neurons:
  • To elucidate how individual neurons integrate excitatory inputs.
  • To understand the role of intrinsic neuronal properties and voltage-gated ion channels in this process.
  • To understand the role of local GABAergic inhibition in this process, and to examine the underlying elementary inhibitory microcircuits.
A major focus of the laboratory is to understand changes in these properties in chronic epilepsy:
  • To identify changes in intrinsic properties of neurons, and the molecular basis of underlying changes in voltage-gated currents.
  • How intrinsic plasticity affects elementary integrative properties of neurons.
  • How neuronal microcircuitry is altered in epilepsy.
  • How intrinsic changes in neurons contribute to the development of pharmacoresistance in epilepsy patients.


Life and Brain Center Experimental Epileptology and Cognition Research

Sigmund-Freud Str. 25
53105 Bonn
Klinische Forschung
Forschung & Entwicklung
Forschung & Lehre
Klinik & Praxis