Uni Goettingen, Abt. Biochemie 2

The institute's longstanding interest in the biogenesis of lysosomes is stimulated by the existence of a spectrum of congenital disorders in man that affect the function of lysosomes. The studies included the identification of new molecular defects, the generation of transgenic mice to study the function of genes encoding lysosomal proteins and proteins involved in lysosome biogenesis and the use of mouse models for human congenital disorders to study the pathophysiology of the diseases and the effectiveness of new therapeutic approaches. A number of studies have focussed on the identification of lysosomal trafficking signals in membrane proteins, and their recognition by the transport machinery. Current projects focus on the regulation of the interaction of cytoplasmic adaptors with the lysosomal transport signals in membrane proteins, on the function of several major lysosomal membrane proteins, on a novel protein modification that so far has been found only in the catalytic center of sulfatases, and the molecular defects and pathophysiology in a new group of congenital disorders in which the N-glycosylation of glycoproteins is defective.


Uni Goettingen, Abt. Biochemie 2

Heinrich-Dueker-Weg 12
37073 Göttingen
Forschung & Entwicklung
Forschung & Lehre