The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 14,000 employees in more than 50 specialized clinical departments with almost 2,500 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.
Postdoctoral Researcher - Translational AI in Neuropathology (m/f/d)
The Department of Neuropathology is one of the world's leading reference centres for CNS tumour diagnostics. We co-developed the DNA methylation-based classifier for CNS tumours and continue to expand it (Capper et al., 2018; Sill et al., 2025), and we combine fully digitised histopathology, genome-wide methylation profiling, panel and long-read sequencing and spatial multi-omics with deeply annotated outcome data across tens of thousands of cases (Ritter et al., Nat Cancer 2026; Maas et al., Nat Genetics 2026). Our recent work includes Hetairos, a histology-based AI model that predicts CNS tumour methylation subtypes directly from H&E slides (Jin et al., Nat Cancer 2026), and we are the coordinating site of the EUcanAI (European Unified Cancer diagnostics and treatment AI agent) consortium, an EIC Pathfinder Challenge project on generative AI agents for cancer diagnosis and treatment.
We are now expanding our activities in translational artificial intelligence and are looking for an ambitious postdoctoral researcher who wants to grow into the leadership of an independent research group. You will develop foundation and multimodal models that integrate histomorphology, DNA methylation, sequencing, spatial and clinical data, to address unmet clinical needs (risk stratification, therapy response, identification and characterization of rare entities, AI-supported process optimization) and take models from retrospective proof of concept through prospective validation towards certified diagnostic use.
As a key member of our interdisciplinary team of physicians, biologists and computer scientists, you will work directly alongside the neuropathologists who sign out the diagnoses and with the data your models learn from. We are a key part of the Heidelberg (neuro)-oncology ecosystem and enjoy close collaboration with diverse clinical and technical departments on campus as well as active partnerships with renowned international institutions.
We will actively support you in building your own scientific profile, in acquiring independent third-party funding and in your habilitation - with the clear perspective of establishing your own research group within the department.
Selected recent work from the department
- Jin D, et al. Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes. Nat Cancer. 2026;7:884-898. doi:10.1038/s43018-026-01186-3
- Sill M, et al. Advancing CNS tumor diagnostics with expanded DNA methylation-based classification. Cancer Cell. 2025;44:340-354. doi:10.1016/j.ccell.2025.11.002
- Maas SLN, et al. A microenvironment-determined risk continuum refines subtyping in meningioma and reveals determinants of machine learning-based tumor classification. Nat Genet. 2026;58:341-354. doi:10.1038/s41588-025-02475-w
- Capper D, et al. DNA methylation-based classification of central nervous system tumours. Nature. 2018;555:469-474. doi:10.1038/nature26000
- Job-ID: V000016389
- Field of application: Neuropathologie
- Location: Heidelberg
- Start date: 01.12.2026
- Job Category: Science and teaching
- Working hours: full-time (100%)
- Limitation: Temporary (3 Jahre)
- Contract: TV-L
Your Tasks
As a key member of our interdisciplinary team, you will:
- Develop and adapt foundation and multimodal models integrating histomorphology, -DNA methylation, sequencing, spatial and clinical data
- Establish reproducible training and inference pipelines on our in-house and the central state academic GPU infrastructure
- Co-supervise doctoral, MD and master's students and contribute to grant applications (DFG, ERC, EU, BMBF, foundations) with the aim of acquiring your own third-party funding
- Publish and present at conferences, present the work at national and international meetings and represent the department in research networks such as EUcanA
Your profile
- PhD or MD/PhD in computer science, computational biology, biomedical engineering, physics, mathematics, medicine or a related discipline
- Track record in machine learning applied to biomedical imaging and/or omics data, documented by publications in leading journals or conferences
- Ambition to develop an independent research profile and to grow into the leadership of a research group; first experience in supervising students or in grant writing is a plus
- Excellent written and spoken English communication skills; German is welcome but not a prerequisite
- Ability to work independently and within a collaborative, interdisciplinary team, and awareness of the role's relevance for patient care
What we offer
- Collectively agreed remuneration TV-L E13, attractive company pension scheme (VBL)
- 30 days vacation
- Sustainable travel: job ticket
- Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
- Wide range of health, prevention and sports offers
- Access to one of the world's largest clinically annotated CNS tumour cohorts and continuously growing multimodal datasets with linked molecular and outcome data
- State-of-the-art research infrastructure including digital pathology, dedicated GPU computing and comprehensive in-house platforms for sequencing, proteomics and spatial omics technologies
- A truly translational research environment where AI innovations can progress from discovery to routine diagnostic application
- A structured career path towards scientific independence through mentoring, support for third-party funding acquisition, habilitation opportunities and the prospect of establishing your own research group
- Close interdisciplinary collaboration with leading experts at UKHD, DKFZ, KiTZ, EUcanAI and internationally renowned research institutions worldwide
Note: The UKHD is subject to the provisions of the Infektionsschutzgesetz. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.
The UKHD embraces diversity and values diversity.
Regardless of age, gender, personal identity, disability, origin or religion, we offer everyone the same opportunities. If one gender is underrepresented in a particular area, we place particular emphasis on counteracting this imbalance. If they have the same aptitude, qualifications and professional performance, we give priority to people with severe disabilities when considering them for vacancies.
Contact & Application
For questions regarding this position, please contact Prof. Dr. Dr. med. Felix Sahm via Felix.sahm(at)med.uni-heidelberg.de.
Your career track towards independent group leadership
We look forward to receiving your application online.
Neuropathologie
Prof. Dr. Dr. med. Felix Sahm Ärztlicher Direktor
Im Neuenheimer Feld 224
69120 Heidelberg
Felix.sahm(at)med.uni-heidelberg.de
