The University Hospital Essen offers first class medical services in the Ruhr metropolis. Every year, 225.000 patients are treated in 30 clinics, 27 institutes and specialized centers. The over 8.000 employees offer medical care with state-of-the art diagnosis and therapies, which meet highest international standards. Patient care is connected with basic and translational research at an internationally competitive level.
1 PhD position (m/f/d)
associated with the DFG-funded Research Training Group 2989 (RTG 2989)
(pay grade: EG 13 TV-L 65%)
associated with the DFG-funded Research Training Group 2989 (RTG 2989)
(pay grade: EG 13 TV-L 65%)
Work Area: Institute of Medical Microbiology, group of Prof. Dr. Astrid M. Westendorf ( https://medizinische-mikrobiologie.uk-essen.de/lehrstuhl-fuer-infektionsimmunologie/ )
Contract duration: 01.04.2026 - 31.03.2030
The advertised position is part of the DFG-funded Research Training Group 2989 (RTG 2989) “Targeting cellular interfaces in Reperfused Acute Myocardial Infarction” ( https://www.uni-due.de/grk2989/home.php ) and assigned to project 4 “Targeting the Microbiome”.
Patients with acute myocardial infarction often exhibit dysbiosis of the intestinal microbiome, linked to poorer outcomes and severity of cardiovascular disease. Preliminary data obtained in a mouse model of myocardial infarction indicate alterations in the gut microbiota composition and distribution of immune cells in gut-associated lymphoid tissue, however, the underlying mechanisms remain unclear. This project aims to analyze how reperfused acute myocardial infarction affects the intestinal microbiome and how, in return, mediators of the gut microbiota affect the heart along the gut-heart-axis.
Patients with acute myocardial infarction often exhibit dysbiosis of the intestinal microbiome, linked to poorer outcomes and severity of cardiovascular disease. Preliminary data obtained in a mouse model of myocardial infarction indicate alterations in the gut microbiota composition and distribution of immune cells in gut-associated lymphoid tissue, however, the underlying mechanisms remain unclear. This project aims to analyze how reperfused acute myocardial infarction affects the intestinal microbiome and how, in return, mediators of the gut microbiota affect the heart along the gut-heart-axis.
PhD position (m/f/d) - Immunology and Microbiology
Activities and responsibilities
The RTG 2989 focuses on exploring distinct cellular interfaces in reperfused acute myocardial infarction, encompassing the immune system, vasculature, and cardiomyocytes. Its objective is to identify novel treatment options for myocardial infarction patients. To ensure comprehensive training, the RTG 2989 integrates cardiovascular scientists with researchers from infection/immunology. The RTG 2989 introduces a unique program cultivating doctoral students' clinical and basic scientific skills for successful research. Key features include standardized animal models, patient cohorts supervised by the Cardiac Trial Unit, Tandem supervison pairing clinicians with basic scientist and a mentoring program.
Qualification profile
- Talented and enthusiastic candidates with high interest in basic and translational research
- Strong Diploma/Master degree in Biology, Immunology, Microbiology, Experimental Medicine or related fields
- High motivation and commitment for active cross-disciplinary collaboration
- Fluent in spoken and written English (knowledge of German is not a requirement)
- Willingness to work with laboratory animals
- Very good skills in independent working, organization, communication, and team work
- Active participation in the RTG program
We offer
- Innovative cross-disciplinary scientific training for PhD and MD students at the interface between infection/immunology and cardiovascular research
- Training in transferable academic and soft skills
- Funding for active participation in workshops and conferences and international visits to collaboration partners
- Regular supervision and mentoring
- Excellent career opportunities
- Interdisciplinary work with colleagues from other departments
- Working with modern equipment and certified quality standards
- Family-friendly corporate culture
Interested candidates should fill in the application form on https://www.uni-due.de/grk2989/opportunities.php and send it together with your curriculum vitae, covering letter, two reference letters and copies of all performance records and all university degrees in one pdf file only within 2 weeks after publication to email. Only applications that fulfill all the formal requirements will be considered!
Contact:
Dr. Annette Eyking-Singer
Scientific Coordinator, Institute of Medical Microbiology, University Hospital Essen, Virchowstraße 179, 45147 Essen, Germany
We use your data exclusively for application purposes in accordance with the applicable data protection regulations. Further information can be found in the privacy statement on our homepage at: www.uk-essen.de.
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